FN Archimer Export Format
PT J
TI Infectivity of GI and GII noroviruses established from oyster related outbreaks
BT 
AF THEBAULT, Anne
   TEUNIS, Peter F. M.
   LE PENDU, Jacques
   LE GUYADER, Soizick
   DENIS, Jean-Baptiste
AS 1:1;2:2,3;3:4,5,6;4:7;5:8;
FF 1:;2:;3:;4:PDG-RBE-SG2M-LSEM;5:;
C1 ANSES, F-94701 Maisons Alfort, France.
   Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
   Rollins Sch Publ Hlth, Atlanta, GA USA.
   INSERM, Nantes, France.
   Univ Nantes, Nantes, France.
   CNRS, Nantes, France.
   IFREMER, Nantes, France.
   INRA, Jouy En Josas, France.
C2 ANSES, FRANCE
   RIVM, NETHERLANDS
   ROLLINS SCH PUBL HLTH, USA
   INSERM, FRANCE
   UNIV NANTES, FRANCE
   CNRS, FRANCE
   IFREMER, FRANCE
   INRA, FRANCE
SI NANTES
SE PDG-RBE-SG2M-LSEM
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-p187
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
IF 2.378
TC 56
UR https://archimer.ifremer.fr/doc/00148/25927/24030.pdf
LA English
DT Article
DE ;Norovirus;Shellfish;Bayesian analysis;Dose-response relationship;Fucosyltransferases
AB Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015-0.61] for GI and 0.4[0.04-0.61] for GII, and for illness 0.13[0.007-0.39] for GI and 0.18[0.017-0.42] for GII. Se-subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.
PY 2013
PD JUL
SO Epidemics
SN 1755-4365
PU Elsevier Science Bv
VL 5
IS 2
UT 000320506900005
BP 98
EP 110
DI 10.1016/j.epidem.2012.12.004
ID 25927
ER

EF