FN Archimer Export Format
PT J
TI Occurrence of venlafaxine residues and its metabolites in marine mussels at trace levels: development of analytical method and a monitoring program
BT 
AF BUENO, M. J. Martinez
   BOILLOT, C.
   MUNARON, Dominique
   FENET, H.
   CASELLAS, C.
   GOMEZ, E.
AS 1:1;2:1;3:2;4:1;5:1;6:1;
FF 1:;2:;3:PDG-ODE-LITTORAL-LERLR;4:;5:;6:;
C1 Univ Montpellier, Hydrosci Montpellier UMR 5569, Dept Environm Sci & Publ Hlth, F-34000 Montpellier, France.
   IFREMER, Environm Resources Labs Languedoc Roussillon, F-34203 Sete, France.
C2 UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
SI SETE
SE PDG-ODE-LITTORAL-LERLR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.436
TC 41
TU CNRS
   IFREMER
   IRD
   UNIVERSITE MONTPELLIER
UR https://archimer.ifremer.fr/doc/00168/27877/26123.pdf
   https://archimer.ifremer.fr/doc/00168/27877/26610.pdf
LA English
DT Article
CR PEPSEA-1
BO L'Europe
DE ;Antidepressant;Emerging contaminants;Transformation products;Marine organisms;Orbitrap;QuEChERS
AB Coastal areas are subject to growing pressures and impacts due to increasing of the human activities. Lipophilic organic contaminants, such as polycyclic aromatic hydrocarbons (PAHs) or polychlorinated biphenyls (PCBs), have been monitored for decades within biomonitoring programs. However, until now, little information on the detection of called “emerging contaminants” as hydrophilic organic compounds, in the marine environment and no data on its metabolites or transformation products in marine organisms is available. In this way, a sensitive analytical methodology for identification and confirmation of venlafaxine residues (VEN) and five of its main metabolites in the marine mussels Mytilus galloprovincialis was validated. The sample preparation procedure was based on the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach. An analytical method was then developed to quantify these compounds at ultra-trace levels by liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS). The strategy was then applied to marine mussels collected from Mediterranean Sea in southeastern France. Residues of the antidepressant VEN were occasionally detected at ng/g dw level. In addition, the approach allowed us to identify and quantify several transformation products in the analyzed samples. N-Desmethylvenlafaxine (NDV) was the most frequently detected metabolite followed by N,O-Di-Desmethylvenlafaxine (NODDV) and O-Desmethylvenlafaxine (ODV).
PY 2014
PD JAN
SO Analytical And Bioanalytical Chemistry
SN 1618-2642
PU Springer Heidelberg
VL 406
IS 2
UT 000329626600023
BP 601
EP 610
DI 10.1007/s00216-013-7477-x
ID 27877
ER

EF