Dietary BMAA Exposure in an Amyotrophic Lateral Sclerosis Cluster from Southern France

Type Article
Date 2013-12
Language English
Author(s) Masseret Estelle1, Banack Sandra2, Boumediene Farid3, Abadie EricORCID4, Brient Luc5, Pernet FabriceORCID4, Juntas-Morales Raoul6, 7, Pageot Nicolas6, 7, Metcalf James2, Cox Paul2, Camu William6, 7
Affiliation(s) 1 : Univ Montpellier 2, Inst Rech Dev, Unite Mixte Rech 5119, Ecol Syst Marins Cotiers, Montpellier, France.
2 : Inst Ethnomed, Jackson, WY USA.
3 : Univ Limoges, Unite Mixte Rech 1094, Limoges, France.
4 : IFREMER, Lab Environm Ressources Languedoc Roussillon, Sete, France.
5 : Univ Rennes 1, Unite Mixte Rech 6553, Rennes, France.
6 : Ctr Hosp Univ Gui de Chauliac, Amyotroph Lateral Sclerosis Ctr, Montpellier, France.
7 : Univ Montpellier I, INSERM, U1051, Montpellier, France.
Source Plos One (1932-6203) (Public Library Science), 2013-12 , Vol. 8 , N. 12 , P. e83406
DOI 10.1371/journal.pone.0083406
WOS© Times Cited 83
Abstract Background

Dietary exposure to the cyanotoxin BMAA is suspected to be the cause of amyotrophic lateral sclerosis in the Western Pacific Islands. In Europe and North America, this toxin has been identified in the marine environment of amyotrophic lateral sclerosis clusters but, to date, only few dietary exposures have been described.

Objectives

We aimed at identifying cluster(s) of amyotrophic lateral sclerosis in the Hérault district, a coastal district from Southern France, and to search, in the identified area(s), for the existence of a potential dietary source of BMAA.

Methods

A spatio-temporal cluster analysis was performed in the district, considering all incident amyotrophic lateral sclerosis cases identified from 1994 to 2009 by our expert center. We investigated the cluster area with serial collections of oysters and mussels that were subsequently analyzed blind for BMAA concentrations.

Results

We found one significant amyotrophic lateral sclerosis cluster (p = 0.0024), surrounding the Thau lagoon, the most important area of shellfish production and consumption along the French Mediterranean coast. BMAA was identified in mussels (1.8 µg/g to 6.0 µg/g) and oysters (0.6 µg/g to 1.6 µg/g). The highest concentrations of BMAA were measured during summer when the highest picocyanobacteria abundances were recorded.

Conclusions

While it is not possible to ascertain a direct link between shellfish consumption and the existence of this ALS cluster, these results add new data to the potential association of BMAA with sporadic amyotrophic lateral sclerosis, one of the most severe neurodegenerative disorder.
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Masseret Estelle, Banack Sandra, Boumediene Farid, Abadie Eric, Brient Luc, Pernet Fabrice, Juntas-Morales Raoul, Pageot Nicolas, Metcalf James, Cox Paul, Camu William (2013). Dietary BMAA Exposure in an Amyotrophic Lateral Sclerosis Cluster from Southern France. Plos One, 8(12), e83406. Publisher's official version : https://doi.org/10.1371/journal.pone.0083406 , Open Access version : https://archimer.ifremer.fr/doc/00168/27941/