FN Archimer Export Format
PT J
TI Dietary BMAA Exposure in an Amyotrophic Lateral Sclerosis Cluster from Southern France
BT 
AF MASSERET, Estelle
   BANACK, Sandra
   BOUMEDIENE, Farid
   ABADIE, Eric
   BRIENT, Luc
   PERNET, Fabrice
   JUNTAS-MORALES, Raoul
   PAGEOT, Nicolas
   METCALF, James
   COX, Paul
   CAMU, William
AS 1:1;2:2;3:3;4:4;5:5;6:4;7:6,7;8:6,7;9:2;10:2;11:6,7;
FF 1:;2:;3:;4:PDG-ODE-LITTORAL-LERLR;5:;6:PDG-RBE-PFOM;7:;8:;9:;10:;11:;
C1 Univ Montpellier 2, Inst Rech Dev, Unite Mixte Rech 5119, Ecol Syst Marins Cotiers, Montpellier, France.
   Inst Ethnomed, Jackson, WY USA.
   Univ Limoges, Unite Mixte Rech 1094, Limoges, France.
   IFREMER, Lab Environm Ressources Languedoc Roussillon, Sete, France.
   Univ Rennes 1, Unite Mixte Rech 6553, Rennes, France.
   Ctr Hosp Univ Gui de Chauliac, Amyotroph Lateral Sclerosis Ctr, Montpellier, France.
   Univ Montpellier I, INSERM, U1051, Montpellier, France.
C2 UNIV MONTPELLIER, FRANCE
   INST ETHNOMED, USA
   UNIV LIMOGES, FRANCE
   IFREMER, FRANCE
   UNIV RENNES, FRANCE
   CHU MONTPELLIER, FRANCE
   UNIV MONTPELLIER, FRANCE
SI SETE
   BREST
SE PDG-ODE-LITTORAL-LERLR
   PDG-RBE-PFOM
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 3.534
TC 86
UR https://archimer.ifremer.fr/doc/00168/27941/26234.pdf
LA English
DT Article
AB Background  Dietary exposure to the cyanotoxin BMAA is suspected to be the cause of amyotrophic lateral sclerosis in the Western Pacific Islands. In Europe and North America, this toxin has been identified in the marine environment of amyotrophic lateral sclerosis clusters but, to date, only few dietary exposures have been described.  Objectives  We aimed at identifying cluster(s) of amyotrophic lateral sclerosis in the Hérault district, a coastal district from Southern France, and to search, in the identified area(s), for the existence of a potential dietary source of BMAA.  Methods  A spatio-temporal cluster analysis was performed in the district, considering all incident amyotrophic lateral sclerosis cases identified from 1994 to 2009 by our expert center. We investigated the cluster area with serial collections of oysters and mussels that were subsequently analyzed blind for BMAA concentrations.  Results  We found one significant amyotrophic lateral sclerosis cluster (p = 0.0024), surrounding the Thau lagoon, the most important area of shellfish production and consumption along the French Mediterranean coast. BMAA was identified in mussels (1.8 µg/g to 6.0 µg/g) and oysters (0.6 µg/g to 1.6 µg/g). The highest concentrations of BMAA were measured during summer when the highest picocyanobacteria abundances were recorded.  Conclusions  While it is not possible to ascertain a direct link between shellfish consumption and the existence of this ALS cluster, these results add new data to the potential association of BMAA with sporadic amyotrophic lateral sclerosis, one of the most severe neurodegenerative disorder.
PY 2013
PD DEC
SO Plos One
SN 1932-6203
PU Public Library Science
VL 8
IS 12
UT 000328734200083
DI 10.1371/journal.pone.0083406
ID 27941
ER

EF