FN Archimer Export Format
PT J
TI Identification of Hypoxia-Regulated Genes in the Liver of Common Sole (Solea solea ) Fed Different Dietary Lipid Contents
BT 
AF MAZURAIS, David
   FERRARESSO, Serena
   GATTA, Pier Paolo
   DESBRUYERES, Elisabeth
   SEVERE, Armelle
   CORPOREAU, Charlotte
   CLAIREAUX, Guy
   BARGELLONI, Luca
   ZAMBONINO-INFANTE, Jose-Luis
AS 1:1;2:2;3:3;4:1;5:1;6:1;7:4;8:2;9:1;
FF 1:PDG-RBE-PFOM-ARN;2:;3:;4:PDG-RBE-PFOM-ARN;5:PDG-RBE-PFOM-ARN;6:PDG-RBE-PFOM-PI;7:;8:;9:PDG-RBE-PFOM-ARN;
C1 IFREMER, CS 10070, Unite Physiol Fonct Organismes Marins, UMR LEMAR 6539, F-29280 Plouzane, France.
   Univ Padua, Dept Comparat Biomed & Food Sci, I-35020 Legnaro, Italy.
   Univ Bologna, Alma Mater Studiorum Dipartimento Sci Med Vet, I-40064 Bologna, Italy.
   Univ Bretagne Occidentale, Inst Univ Europeen Mer, LEMAR UMR 6539, F-29280 Plouzane, France.
C2 IFREMER, FRANCE
   UNIV PADUA, ITALY
   UNIV BOLOGNA, ITALY
   UBO, FRANCE
SI BREST
SE PDG-RBE-PFOM-ARN
   PDG-RBE-PFOM-PI
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-europe
   copubli-univ-france
IF 3.269
TC 13
UR https://archimer.ifremer.fr/doc/00169/28062/26474.pdf
LA English
DT Article
DE ;Fish;Hypoxia;Nutrition;Liver;Transcriptome;AMPK
AB Coastal systems could be affected by hypoxic events brought about by global change. These areas are essential nursery habitats for several fish species including the common sole (Solea solea L.). Tolerance of fish to hypoxia depends on species and also on their physiological condition and nutritional status. Indeed, high dietary lipid content has been recently shown to negatively impact the resistance of sole to a severe hypoxic challenge. In order to study the molecular mechanisms involved in the early response to hypoxic stress, the present work examined the hepatic transcriptome in common sole fed diets with low and high lipid content, exposed to severe hypoxia. The activity of AMP-activated protein kinase (AMPK) was also investigated through the quantification of threonine-172 phosphorylation in the alpha subunit. The results show that hypoxia consistently regulates several actors involved in energy metabolism pathways and particularly AMPKα, as well as some involved in cell growth and maintenance or unfolded protein response. Our findings reveal that (1) the expression of genes involved in biological processes with high energy cost or implicated in aerobic ATP synthesis was down-regulated by hypoxia, contrary to genes involved in neoglucogenesis or in angiogenesis, (2) the consumption of high lipid induced regulation of metabolic pathways going against this energy saving, and (3) this control was fine-tuned by the regulation of several transcriptomic factors. These results provide insight into the biological processes involved in the hepatic response to hypoxic stress and underline the negative impact of high lipid consumption on the tolerance of common sole to hypoxia
PY 2014
PD JUL
SO Marine Biotechnology
SN 1436-2228
PU Springer
VL 16
IS 3
UT 000334996700004
BP 277
EP 288
DI 10.1007/s10126-013-9545-9
ID 28062
ER

EF