FN Archimer Export Format
PT J
TI Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
BT 
AF BAUDELET, Paul-Hubert
   GAGEZ, Anne-Laure
   BERARD, Jean-Baptiste
   JUIN, Camille
   BRIDIAU, Nicolas
   KAAS, Raymond
   THIERY, Valerie
   CADORET, Jean-Paul
   PICOT, Laurent
AS 1:1;2:1,2;3:3;4:1;5:1;6:3;7:1;8:3;9:1;
FF 1:;2:;3:PDG-RBE-BRM-PBA;4:;5:;6:PDG-RBE-BRM-PBA;7:;8:PDG-RBE-BRM-PBA;9:;
C1 Univ La Rochelle, UMRi CNRS LIENSs 7266, F-17042 La Rochelle, France.
   Univ La Rochelle, UMRi CNRS LIENSs 7266, F-17071 La Rochelle 9, France.
   IFREMER Ctr Nantes, IFREMER, Lab PBA, F-44311 Nantes, France.
C2 UNIV LA ROCHELLE, FRANCE
   UNIV LA ROCHELLE, FRANCE
   IFREMER, FRANCE
SI NANTES
SE PDG-RBE-BRM-PBA
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.512
TC 32
UR https://archimer.ifremer.fr/doc/00177/28818/27289.pdf
LA English
DT Article
DE ;pigments;microalgae;Cyanophora paradoxa;melanoma;cancer;apoptosis;zeaxanthin;cryptoxanthin
AB The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 mu g.mL(-1). Flash chromatography of the Cp ethanol extract, devoid of c-phycocyanin and allophycocyanin, enabled the collection of eight fractions, four of which strongly inhibited cancer cells growth at 100 mu g.mL(-1). Particularly, two fractions inhibited more than 90% of the melanoma cells growth, one inducing apoptosis in the three cancer cells lines. The detailed analysis of Cp pigment composition resulted in the discrimination of 17 molecules, ten of which were unequivocally identified by high resolution mass spectrometry. Pheophorbide a, beta-cryptoxanthin and zeaxanthin were the three main pigments or derivatives responsible for the strong cytotoxicity of Cp fractions in cancer cells. These data point to Cyanophora paradoxa as a new microalgal source to purify potent anticancer pigments, and demonstrate for the first time the strong antiproliferative activity of zeaxanthin and beta-cryptoxanthin in melanoma cells.
PY 2013
PD NOV
SO Marine Drugs
SN 1660-3397
PU Mdpi Ag
VL 11
IS 11
UT 000330521400016
BP 4390
EP 4406
DI 10.3390/md11114390
ID 28818
ER

EF