FN Archimer Export Format PT C TI Identification of paralytic shellfish poisons using liquid chromatography / ion mobility - high resolution mass spectrometry BT AF POYER, Salomé LOUTELIER-BOURHIS, Corinne MONDEGUER, Florence COADOU, Gaël HUBERT-ROUX, Marie ENCHE, Julien BOSSEE, Anne HESS, Philipp AFONSO, Carlos AS 1:1;2:1;3:2;4:1;5:1;6:3;7:3;8:2;9:3; FF 1:;2:;3:PDG-ODE-LITTORAL-PHYC;4:;5:;6:;7:;8:PDG-ODE-LITTORAL-PHYC;9:; C1 Normandie Université, COBRA, UMR 6014 et FR 3038 ; Université de Rouen ; INSA de Rouen ; CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France. IFREMER, Laboratoire Phycotoxines, F-44311 Nantes 03, France DGA Maîtrise NRBC, département Analyse Chimique, F-91710 Vert Le Petit, France C2 UNIV ROUEN, FRANCE IFREMER, FRANCE CDNBC, FRANCE SI NANTES SE PDG-ODE-LITTORAL-PHYC UR https://archimer.ifremer.fr/doc/00179/29039/27475.pdf LA English DT Poster AB Saxitoxin and its analogues also called paralytic shellfish poisons (PSPs) are very potent neurotoxins [1] produced by dinoflagellates and referenced as chemical weapon in the chemical warfare convention (CWC). The official detection methods for these toxins present limitations concerning their speed and reliability [2]. Due to the presence of isomers, not differentiable by mass spectrometry (MS), an upstream separation is necessary. In order to separate saxitoxin analogues, hydrophilic interaction liquid chromatography (HILIC) and ion mobility (IM) were used. Those techniques respectively developed for high polar compounds and three dimensional structure differentiation are particularly well adapted to the separation of PSPs. This HILIC/IM-MS coupling was used to develop a fast, reproducible and sensitive method for the separation and the detection of the PSPs PY 2013 PD MAY ID 29039 ER EF