Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment

Type Article
Date 2014-12
Language English
Author(s) Vignet Caroline1, Devier Marie-Hélène2, Le Menach Karyn2, Lyphout Laura3, Potier Jeremy1, Cachot Jerome2, Budzinski Helene2, Begout Marie-LaureORCID3, Cousin XavierORCID1, 4
Affiliation(s) 1 : IFREMER, Lab Ecotoxicol, F-17137 Lhoumeau, France.
2 : Univ Bordeaux 1, EPOC, UMR CNRS 5805, F-33405 Talence, France.
3 : IFREMER, Lab Ressources Halieut, F-17137 Lhoumeau, France.
4 : INRA LPGP, F-35042 Rennes, France.
Source Environmental Science And Pollution Research (0944-1344) (Springer Heidelberg), 2014-12 , Vol. 21 , N. 24 , P. 13877-13887
DOI 10.1007/s11356-014-2585-5
WOS© Times Cited 68
Keyword(s) Danio rerio, Polycyclic aromatic hydrocarbon, Lifecycle, Anxiety-like behavior, Offspring
Abstract A natural sediment spiked with three individual polycyclic aromatic hydrocarbons (PAHs; pyrene, phenanthrene and benzo[a]pyrene) was used to expose zebrafish embryos and larvae during 4 days. The total PAH concentration was 4.4 μg g−1 which is in the range found in sediment from contaminated areas. Quantification of metabolites in the larvae after exposure confirmed the actual contamination of the larvae and indicated an active metabolism especially for pyrene and benzo[a]pyrene. After a transfer in a clean medium, the larvae were reared to adulthood and evaluated for survival, growth, reproduction, and behavior. Measured endpoints revealed a late disruption of growth (appearing at 5 months) and a trend toward a lower reproductive ability. Adults of embryos exposed to sediment spiked with PAHs displayed lethargic and/or anxiety-like behaviors. This latter behavior was also identified in offspring at larval stage. All together, these effects could have detrimental consequences on fish performances and contribution to recruitment.
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Vignet Caroline, Devier Marie-Hélène, Le Menach Karyn, Lyphout Laura, Potier Jeremy, Cachot Jerome, Budzinski Helene, Begout Marie-Laure, Cousin Xavier (2014). Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment. Environmental Science And Pollution Research, 21(24), 13877-13887. Publisher's official version : https://doi.org/10.1007/s11356-014-2585-5 , Open Access version : https://archimer.ifremer.fr/doc/00188/29909/