TY - JOUR T1 - Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment A1 - Vignet,Caroline A1 - Devier,Marie-Hélène A1 - Le Menach,Karyn A1 - Lyphout,Laura A1 - Potier,Jeremy A1 - Cachot,Jerome A1 - Budzinski,Helene A1 - Begout,Marie-Laure A1 - Cousin,Xavier AD - IFREMER, Lab Ecotoxicol, F-17137 Lhoumeau, France. AD - Univ Bordeaux 1, EPOC, UMR CNRS 5805, F-33405 Talence, France. AD - IFREMER, Lab Ressources Halieut, F-17137 Lhoumeau, France. AD - INRA LPGP, F-35042 Rennes, France. UR - https://doi.org/10.1007/s11356-014-2585-5 DO - 10.1007/s11356-014-2585-5 KW - Danio rerio KW - Polycyclic aromatic hydrocarbon KW - Lifecycle KW - Anxiety-like behavior KW - Offspring N2 - A natural sediment spiked with three individual polycyclic aromatic hydrocarbons (PAHs; pyrene, phenanthrene and benzo[a]pyrene) was used to expose zebrafish embryos and larvae during 4 days. The total PAH concentration was 4.4 μg g−1 which is in the range found in sediment from contaminated areas. Quantification of metabolites in the larvae after exposure confirmed the actual contamination of the larvae and indicated an active metabolism especially for pyrene and benzo[a]pyrene. After a transfer in a clean medium, the larvae were reared to adulthood and evaluated for survival, growth, reproduction, and behavior. Measured endpoints revealed a late disruption of growth (appearing at 5 months) and a trend toward a lower reproductive ability. Adults of embryos exposed to sediment spiked with PAHs displayed lethargic and/or anxiety-like behaviors. This latter behavior was also identified in offspring at larval stage. All together, these effects could have detrimental consequences on fish performances and contribution to recruitment. Y1 - 2014/12 PB - Springer Heidelberg JF - Environmental Science And Pollution Research SN - 0944-1344 VL - 21 IS - 24 SP - 13877 EP - 13887 ID - 29909 ER -