FN Archimer Export Format PT J TI Getting the most out of it: Optimal experiments for parameter estimation of microalgae growth models BT AF MUNOZ-TAMAYO, Rafael MARTINON, Pierre BOUGARAN, Gael MAIRET, Francis BERNARD, Olivier AS 1:1;2:2;3:3;4:1;5:1,4; FF 1:;2:;3:PDG-RBE-BRM-PBA;4:;5:; C1 BIOCORE INRIA, F-06902 Sophia Antipolis, France. Ecole Polytech, CMAP, Commands INRIA Saclay, F-91128 Palaiseau, France. IFREMER, Lab Physiol & Biotechnol Algues, F-44311 Nantes 3, France. LOV UPMC CNRS, UMR 7093, Stn Zool, F-06234 Villefranche Sur Mer, France. C2 INRIA, FRANCE ECOLE POLYTECH, FRANCE IFREMER, FRANCE UNIV PARIS 06, FRANCE SI AUTRE NANTES SE AUTRE PDG-RBE-BRM-PBA IN WOS Ifremer jusqu'en 2018 copubli-france copubli-univ-france IF 2.653 TC 22 UR https://archimer.ifremer.fr/doc/00191/30252/28684.pdf LA English DT Article DE ;Biofuel;Biological processes;Modelling;Parameter identification;Optimal experiment design AB Mathematical models are expected to play a pivotal role for driving microalgal production towards a profitable process of renewable energy generation. To render models of microalgae growth useful tools for prediction and process optimization, reliable parameters need to be provided. This reliability implies a careful design of experiments that can be exploited for parameter estimation. In this paper, we provide guidelines for the design of experiments with high informative content based on optimal experiment techniques to attain an accurate parameter estimation. We study a real experimental device devoted to evaluate the effect of temperature and light on microalgae growth. On the basis of a mathematical model of the experimental system, the optimal experiment design problem was formulated and solved with both static (constant light and temperature) and dynamic (time varying light and temperature) approaches. Simulation results indicated that the optimal experiment design allows for a more accurate parameter estimation than that provided by the existing experimental protocol. For its efficacy in terms of the maximum likelihood properties and its practical aspects of implementation, the dynamic approach is recommended over the static approach. PY 2014 PD JUL SO Journal Of Process Control SN 0959-1524 PU Elsevier Sci Ltd VL 24 IS 6 UT 000338806000027 BP 991 EP 1001 DI 10.1016/j.jprocont.2014.04.021 ID 30252 ER EF