FN Archimer Export Format PT J TI Detecting past changes of effective population size BT AF NIKOLIC, Natacha CHEVALET, Claude AS 1:1;2:2,3,4; FF 1:PDG-RBE-DOI;2:; C1 IFREMER La Reunion, Le Port, France. INRA, F-31326 Castanet Tolosan, France. Univ Toulouse, INP, ENSAT, Castanet Tolosan, France. Univ Toulouse, INP, ENVT, Toulouse, France. C2 IFREMER, FRANCE INRA, FRANCE UNIV TOULOUSE, FRANCE UNIV TOULOUSE, FRANCE SI LA REUNION SE PDG-RBE-DOI IN WOS Ifremer jusqu'en 2018 copubli-france copubli-p187 copubli-univ-france IF 3.896 TC 39 UR https://archimer.ifremer.fr/doc/00194/30565/28986.pdf https://archimer.ifremer.fr/doc/00194/30565/29469.pdf LA English DT Article DE ;Atlantic salmon;effective population size;microsatellites;past demography AB Understanding and predicting population abundance is a major challenge confronting scientists. Several genetic models have been developed using microsatellite markers to estimate the present and ancestral effective population sizes. However, to get an overview on the evolution of population requires that past fluctuation of population size be traceable. To address the question, we developed a new model estimating the past changes of effective population size from microsatellite by resolving coalescence theory and using approximate likelihoods in a Monte Carlo Markov Chain approach. The efficiency of the model and its sensitivity to gene flow and to assumptions on the mutational process were checked using simulated data and analysis. The model was found especially useful to provide evidence of transient changes of population size in the past. The times at which some past demographic events cannot be detected because they are too ancient and the risk that gene flow may suggest the false detection of a bottleneck are discussed considering the distribution of coalescence times. The method was applied on real data sets from several Atlantic salmon populations. The method called VarEff (Variation of Effective size) was implemented in the R package VarEff and is made available at https://qgsp.jouy.inra.fr and at http://cran.r-project.org/web/packages/VarEff. PY 2014 PD JUL SO Evolutionary Applications SN 1752-4571 PU Wiley-blackwell VL 7 IS 6 UT 000338039600005 BP 663 EP 681 DI 10.1111/eva.12170 ID 30565 ER EF