Design Polysaccharides of Marine Origin: Chemical Modifications to Reach Advanced Versatile Compounds

Type Article
Date 2014
Language English
Author(s) Chopin Nathalie1, 2, Guillory Xavier1, Weiss Pierre3, Le Bideau Jean2, Colliec-Jouault SylviaORCID1
Affiliation(s) 1 : IFREMER, Inst Francais Rech Exploitat Mer, Lab Biotechnol & Mol Mat, F-44311 Nantes 03, France.
2 : Univ Nantes, CNRS, Inst Mat Jean Rouxel, F-44322 Nantes 3, France.
3 : Univ Nantes, INSERM, LIAOD, U791, F-44042 Nantes 1, France.
Source Current Organic Chemistry (1385-2728) (Bentham Science Publ Ltd), 2014 , Vol. 18 , N. 7 , P. 867-895
DOI 10.2174/138527281807140515152334
WOS© Times Cited 18
Keyword(s) Alginates, carrageenans, chemical modification, chitin, chitosan, grafting, marine polysaccharide, polymer
Abstract Polysaccharides are among the most abundant macromolecules on Earth. These polymers are easily obtained from various marine resources such as algae, microorganisms and crustacean shells. The structure of these natural carbohydrates is innovative and quite complex. Marine biopolymers represent key scaffolds toward large challenging fields, such as biomedical applications (glycosaminoglycans, regenerative medicine and drug delivery) and tailored biomaterials. Chemical modifications can be applied to modify their final properties in a specific purpose. New functional glycans are achievable and represent a real potential with their intrinsic biocompatibility and biodegradability. Hydroxyl groups are ubiquitous in polysaccharides structure and involved in most of the chemical modifications. The most useful functionalities are ester, ether, amide, amine and alkyl groups. The starting materials could be a natural or depolymerized polymers and the reaction considered with a regioselective point of view. In this review, we will focus on chitin polysaccharide, which is extracted according to industrial processing from exoskeleton of several marine crustaceans. A subsequent deacylation provides chitosan. This marine polysaccharide is very similar to cellulose, a widespread fiber plant organic polymer, except for an amine group on the C2 position instead of a hydroxyl group. Furthermore, seaweeds provide the most abundant sources of polysaccharides: alginates, agar/agarose, carrageenans and fuco dans. In order to improve the original physicochemical and biochemical properties, we will highlight the chemical modifications involving the listed marine polysaccharides of interest.
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