FN Archimer Export Format
PT J
TI Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana
BT 
AF TASIEMSKI, Aurelie
   JUNG, Sascha
   BOIDIN-WICHLACZ, Celine
   JOLLIVET, Didier
   CUVILLIER-HOT, Virginie
   PRADILLON, Florence
   VETRIANI, Costantino
   HECHT, Oliver
   SOENNICHSEN, Frank D.
   GELHAUS, Christoph
   HUNG, Chien-Wen
   THOLEY, Andreas
   LEIPPE, Matthias
   GROETZINGER, Joachim
   GAILL, Francoise
AS 1:1;2:2;3:1;4:3;5:1;6:4;7:5,6;8:2;9:7;10:8;11:9;12:9;13:8;14:2;15:10;
FF 1:;2:;3:;4:;5:;6:PDG-REM-EEP-LEP;7:;8:;9:;10:;11:;12:;13:;14:;15:;
C1 Univ Lille 1, CNRS, UMR8198, Lab GEPV, F-59655 Villeneuve Dascq, France.
   Univ Kiel, Inst Biochem, Kiel, Germany.
   Univ Paris 06, CNRS, UMR7144, Stn Biol,Lab Adaptat & Biol Invertebre Condit Ext, Roscoff, France.
   IFREMER, Ctr Brest, REM EEP LEP, Plouzane, France.
   Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08903 USA.
   Rutgers State Univ, Inst Marine & Coastal Sci, New Brunswick, NJ 08903 USA.
   Univ Kiel, Otto Diels Inst Organ Chem, Kiel, Germany.
   Univ Kiel, Inst Zool, D-24098 Kiel, Germany.
   Univ Kiel, Div Systemat Proteome Res, Inst Expt Med, Kiel, Germany.
   Univ Paris 06, CNRS, BOREA IRD, Museum Natl Hist Nat, Paris, France.
C2 UNIV LILLE, FRANCE
   UNIV KIEL, GERMANY
   UNIV PARIS 06, FRANCE
   IFREMER, FRANCE
   UNIV RUTGERS STATE, USA
   UNIV RUTGERS STATE, USA
   UNIV KIEL, GERMANY
   UNIV KIEL, GERMANY
   UNIV KIEL, GERMANY
   UNIV PARIS 06, FRANCE
SI BREST
SE PDG-REM-EEP-LEP
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
IF 3.234
TC 37
UR https://archimer.ifremer.fr/doc/00219/33052/31517.pdf
   https://archimer.ifremer.fr/doc/00219/33052/31524.pdf
   https://archimer.ifremer.fr/doc/00219/33052/31525.pdf
   https://archimer.ifremer.fr/doc/00219/33052/31526.pdf
   https://archimer.ifremer.fr/doc/00219/33052/31527.pdf
LA English
DT Article
CR MESCAL
   MESCAL_LEG1
   MESCAL_LEG2
BO L'Atalante
AB The emblematic hydrothermal worm Alvinella pompejana is one of the most thermo tolerant animal known on Earth. It relies on a symbiotic association offering a unique opportunity to discover biochemical adaptations that allow animals to thrive in such a hostile habitat. Here, by studying the Pompeii worm, we report on the discovery of the first antibiotic peptide from a deep-sea organism, namely alvinellacin. After purification and peptide sequencing, both the gene and the peptide tertiary structures were elucidated. As epibionts are not cultivated so far and because of lethal decompression effects upon Alvinella sampling, we developed shipboard biological assays to demonstrate that in addition to act in the first line of defense against microbial invasion, alvinellacin shapes and controls the worm's epibiotic microflora. Our results provide insights into the nature of an abyssal antimicrobial peptide (AMP) and into the manner in which an extremophile eukaryote uses it to interact with the particular microbial community of the hydrothermal vent ecosystem. Unlike earlier studies done on hydrothermal vents that all focused on the microbial side of the symbiosis, our work gives a view of this interaction from the host side.
PY 2014
PD APR
SO Plos One
SN 1932-6203
PU Public Library Science
VL 9
IS 4
UT 000346241800015
BP 1
EP 10
DI 10.1371/journal.pone.0095737
ID 33052
ER

EF