FN Archimer Export Format
PT J
TI Immune responses of phenoloxidase and superoxide dismutase in the manila clam Venerupis philippinarum challenged with Vibrio tapetis – Part I: Spatio-temporal evolution of enzymes’ activities post-infection
BT 
AF LE BRIS, Cedric
   RICHARD, Gaelle
   PAILLARD, Christine
   LAMBERT, Christophe
   SEGUINEAU, Catherine
   GAUTHIER, Olivier
   PERNET, Fabrice
   GUERARD, Fabienne
AS 1:1;2:1;3:1;4:1;5:2;6:1;7:2;8:1;
FF 1:;2:;3:;4:;5:;6:;7:PDG-RBE-PFOM;8:;
C1 Univ Bretagne Occidentale, Inst Univ Europeen Mer, LEMAR IUEM UBO, UMR CNRS UBO IRD IFREMER 6539, F-29280 Plouzane, France.
   IFREMER, Lab Physiol Invertebres, LEMAR IUEM UBO, UMR CNRS UBO IRD IFREMER 6539, F-29280 Plouzane, France.
C2 UBO, FRANCE
   IFREMER, FRANCE
SI BREST
SE PDG-RBE-PFOM
UM LEMAR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.025
TC 22
UR https://archimer.ifremer.fr/doc/00221/33257/31733.pdf
LA English
DT Article
DE ;Venerupis philippinarum;Vibrio tapetis;Immunity;Phenoloxidase;Superoxide dismutase
AB Manila clams, Venerupis philippinarum (Adams and Reeve, 1850), were experimentally challenged with two Vibrio tapetis strains: CECT4600T, the causative agent of Brown Ring Disease (BRD); and LP2 supposedly non-pathogenic in V. philippinarum. Changes in phenoloxidase (PO) and superoxide dismutase (SOD), two major enzymes involved in immunity, were studied in two tissues, the mantle and hemolymph for 30 days after infection in the extrapallial cavity. Bacterial infection in V. philippinarum resulted in modulation of PO and SOD activities that was both tissue- and time-dependent. A response at early times was detected in the mantle and was associated with significant increases in PO and SOD activities in LP2- and CECT4600T-challenged clams 36h post injection. This first response in the mantle could be explained by the proximity to the injection region (extrapallial cavity). In the hemolymph the response occurred at later times and was associated with an increase in PO activity and a decrease in SOD activity. As hemolymph is a circulating fluid, this response delay could be due to an “integration time” needed by the organism to counteract the infection. Injections also impacted PO and SOD activities in both tissues and confirmed a difference in pathogenicity between the two V. tapetis strains.
PY 2015
PD JAN
SO Fish & Shellfish Immunology
SN 1050-4648
PU Academic Press Ltd- Elsevier Science Ltd
VL 42
IS 1
UT 000348015700002
BP 16
EP 24
DI 10.1016/j.fsi.2014.10.021
ID 33257
ER

EF