FN Archimer Export Format
PT J
TI The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view
BT 
AF BACHERE, Evelyne
   ROSA, Rafael Diego
   SCHMITT, Paulina
   POIRIER, Aurore
   MEROU, Nicolas
   CHARRIERE, Guillaume
   DESTOUMIEUX-GARZON, Delphine
AS 1:1;2:1,2;3:1,3;4:1;5:1;6:1;7:1;
FF 1:PDG-RBE-IHPE;2:;3:PDG-RBE-BOME-LALR;4:;5:;6:;7:;
C1 Univ Montpellier, CNRS, IFREMER, UMR 5244,IHPE Interact Host Pathogen Environm UPV, F-34095 Montpellier, France.
   Univ Fed Santa Catarina, Dept Cell Biol Embryol & Genet, Lab Immunol Appl Aquaculture, BR-88040900 Florianopolis, SC, Brazil.
   Pontificia Univ Catolica Valparaiso, Inst Biol, Lab Genet & Inmunol Mol, Valparaiso 2373223, Chile.
C2 UNIV MONTPELLIER, FRANCE
   UNIV FED SANTA CATARINA, BRAZIL
   UNIV PONTIFICIA CATOLICA VALPARAISO, CHILE
   IFREMER, FRANCE
SI MONTPELLIER
SE PDG-RBE-IHPE
   PDG-RBE-BOME-LALR
UM IHPE
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
   copubli-sud
IF 3.025
TC 83
UR https://archimer.ifremer.fr/doc/00254/36552/35097.pdf
LA English
DT Article
DE ;Mollusk;Immunity;Antimicrobial peptide;Hemocyte;Defensin
AB Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful conditions including infection and changing environments. We give here cellular and molecular insights into the Crassostrea gigas antimicrobial defense system with focus on antimicrobial peptides and proteins (AMPs). This review highlights the central role of the hemocytes in the modulation and control of oyster antimicrobial response. As vehicles for AMPs and other antimicrobial effectors, including reactive oxygen species (ROS), and together with epithelia, hemocytes provide the oyster with local defense reactions instead of systemic humoral ones. These reactions are largely based on phagocytosis but also, as recently described, on the extracellular release of antimicrobial histones (ETosis) which is triggered by ROS. Thus, ROS can signal danger and activate cellular responses in the oyster. From the current literature, AMP production/release could serve similar functions. We provide also new lights on the oyster genetic background that underlies a great diversity of AMP sequences but also an extraordinary individual polymorphism of AMP gene expression. We discuss here how this polymorphism could generate new immune functions, new pathogen resistances or support individual adaptation to environmental stresses.
PY 2015
PD SEP
SO Fish & Shellfish Immunology
SN 1050-4648
PU Academic Press Ltd- Elsevier Science Ltd
VL 46
IS 1
UT 000358805300006
BP 50
EP 64
DI 10.1016/j.fsi.2015.02.040
ID 36552
ER

EF