FN Archimer Export Format
PT J
TI Active and passive biomonitoring suggest metabolic adaptation in blue mussels (Mytilus spp.) chronically exposed to a moderate contamination in Brest harbor (France)
BT 
AF LACROIX, Camille
   RICHARD, Gaelle
   SEGUINEAU, Catherine
   GUYOMARCH, Julien
   MORAGA, Dario
   AUFFRET, Michel
AS 1:1;2:1;3:1,2;4:3;5:1;6:1;
FF 1:;2:;3:;4:;5:;6:;
C1 Univ Bretagne Occidentale, European Univ Inst Mer, LEMAR, UMR UBO CNRS IRD Ifremer 6539, F-29280 Plouzane, France.
   IFREMER, LPI, UMR 6539, F-29280 Plouzane, France.
   CEDRE, F-29218 Brest 2, France.
C2 UBO, FRANCE
   UBO, FRANCE
   CEDRE, FRANCE
UM LEMAR
IF 3.557
TC 50
UR https://archimer.ifremer.fr/doc/00255/36654/35795.pdf
LA English
DT Article
DE ;Marine biomonitoring;Chronic pollution;Blue mussel Mytilus spp.;Caging;Oxidative stress;Energetic metabolism;Bay of Brest
AB Brest harbor (Bay of Brest, Brittany, France) has a severe past of anthropogenic chemical contamination, but inputs tended to decrease, indicating a reassessment of its ecotoxicological status should be carried out. Here, native and caged mussels (Mytilus spp.) were used in combination to evaluate biological effects of chronic chemical contamination in Brest harbor. Polycyclic aromatic hydrocarbon (PAH) contamination was measured in mussel tissues as a proxy of harbor and urban pollution. Biochemical biomarkers of xenobiotic biotransformation, antioxidant defenses, generation of reducing equivalents, energy metabolism and oxidative damage were studied in both gills and digestive glands of native and caged mussels. In particular, activities of glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), NADP-dependent isocitrate dehydrogenase (IDP), pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK) were measured and lipid peroxidation was assessed by malondialdehyde (MDA) quantification. In addition, a condition index was calculated to assess the overall health of the mussels. Moderate PAH contamination was detected in digestive glands of both native and caged individuals from the exposed site. Modulations of biomarkers were detected in digestive glands of native harbor mussels indicating the presence of a chemical pressure. In particular, results suggested increased biotransformation (GST), antioxidant defenses (CAT), NADPH generation (IDP) and gluconeogenesis (PEPCK), which could represent a coordinated response against chemically-induced cellular stress. Lipid peroxidation assessment and condition index indicated an absence of acute stress in the same mussels suggesting metabolic changes could, at least partially, offset the negative effects of contamination. In caged mussels, only GR was found modulated compared to non-exposed mussels but significant differences in oxidative stress and energy-related biomarkers were observed compared to native harbor mussels. Overall, these results suggested mussels chronically exposed to contamination have set up metabolic adaptation, which may contribute to their survival in the moderately contaminated harbor of Brest. Whether these adaptive traits result from phenotypic plasticity or genetic adaptation needs to be further investigated.
PY 2015
PD MAY
SO Aquatic Toxicology
SN 0166-445X
PU Elsevier Science Bv
VL 162
UT 000353860700015
BP 126
EP 137
DI 10.1016/j.aquatox.2015.03.008
ID 36654
ER

EF