FN Archimer Export Format PT J TI Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections BT AF MOREAU, Pierrick MOREAU, Kevin SEGARRA, Amelie TOURBIEZ, Delphine TRAVERS, Marie-Agnes RUBINSZTEIN, David C. RENAULT, Tristan AS 1:1;2:2;3:1;4:1;5:1;6:2;7:1; FF 1:PDG-RBE-SG2M-LGPMM;2:;3:PDG-RBE-SG2M-LGPMM;4:PDG-RBE-SG2M-LGPMM;5:PDG-RBE-SG2M-LGPMM;6:;7:PDG-RBE; C1 IFREMER, Lab Genet & Pathol Mollusques Marins, Ronce Les Bains, La Tremblade, France. Cambridge Inst Med Res, Dept Med Genet, Cambridge, England. C2 IFREMER, FRANCE CIMR, UK SI LA TREMBLADE NANTES SE PDG-RBE-SG2M-LGPMM PDG-RBE IN WOS Ifremer jusqu'en 2018 copubli-europe IF 9.108 TC 85 UR https://archimer.ifremer.fr/doc/00269/37989/36072.pdf LA English DT Article DE ;autophagy;Crassostrea gigas;OsHV-1;Pacific oyster;Vibrio aestuarianus;ATG;autophagy-related;Atg8-PE;Atg8-phosphatidylethenolamine;DNA;deoxyribonucleic acid;hpi;hours postinfection;LC3-II;cleaved;lipidated and autophagosome-associated form of LC3;MAP1LC3A;B (LC3A;B);microtubule-associated proteins 1 light chain 3 alpha AB Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters. PY 2015 PD MAR SO Autophagy SN 1554-8627 PU Taylor & Francis Inc VL 11 IS 3 UT 000353587600008 BP 516 EP 526 DI 10.1080/15548627.2015.1017188 ID 37989 ER EF