Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions
|Author(s)||Ben Henda Yesmine1, Laamari Mariem1, Lanneluc Isabelle1, Travers Marie-Agnes2, Agogue Helene3, Arnaudin Ingrid1, Bridiau Nicolas1, Maugard Thierry1, Piot Jean-Marie1, Sannier Frederic1, Bordenave-Juchereau Stephanie1|
|Affiliation(s)||1 : Univ La Rochelle, UFR Sci Technol Sante, Lab LIENSs, CNRS,UMR 7266,Approches Mol,Environm Sante, F-17042 La Rochelle 1, France.
2 : IFREMER, SG2M LGPMM, Lab Genet & Pathol Mollusques Marins, F-17390 La Tremblade, France.
3 : Univ La Rochelle, Mol Core Facil, Lab LIENSs, CNRS,UMR7266, F-17000 La Rochelle, France.
|Source||Journal Of Functional Foods (1756-4646) (Elsevier Science Bv), 2015-08 , Vol. 17 , P. 1-10|
|WOS© Times Cited||10|
|Keyword(s)||Bioactive peptides, Obesity, Human white pre-adipocytes', Proliferation, Differentiation, Adipocyte differentiation markers|
|Abstract||The effect of 11 marine-derived cryptides was investigated on proliferation, differentiation and maturation of human white pre-adipocytes (HWP). They were all formerly identified as potent Angiotensin-Converting-Enzyme inhibitors.Val-Trp (VW),Val-Tyr (VY), Lys-Tyr (KY), Lys-Trp (KW), Ile-Tyr (IY), Ala-Pro (AP),Val-Ile-Tyr (VIY), Leu-Lys-Pro (LKP), Gly-Pro-Leu (GPL), Ala-Lys-Lys (AKK) and Val-Ala-Pro (VAP) were previously found in fish products and coproducts as well as other marine resources like wakame. Treatment with AP, VAP and AKK greatly affected viability of HWP during the proliferation period while KW and VW treatment reduced the number of viable cells during the differentiation stage. A GPL and IY incubation during the differentiation stage allowed the decrease of their final lipid content, of the GPDH activity and of the mRNA level of adipocyte markers (aP2, GLUT4, LPL and AGT). Moreover, a down regulation of both PPARγ and C/EBPα expression, two key regulators of adipogenesis,was observed.These findings indicate that small bioactive peptides from marine protein hydrolysates can target adipogenesis and thus could regulate energy metabolism disorders|