TY - JOUR T1 - Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions A1 - Ben Henda,Yesmine A1 - Laamari,Mariem A1 - Lanneluc,Isabelle A1 - Travers,Marie-Agnes A1 - Agogue,Helene A1 - Arnaudin,Ingrid A1 - Bridiau,Nicolas A1 - Maugard,Thierry A1 - Piot,Jean-Marie A1 - Sannier,Frederic A1 - Bordenave-Juchereau,Stephanie AD - Univ La Rochelle, UFR Sci Technol Sante, Lab LIENSs, CNRS,UMR 7266,Approches Mol,Environm Sante, F-17042 La Rochelle 1, France. AD - IFREMER, SG2M LGPMM, Lab Genet & Pathol Mollusques Marins, F-17390 La Tremblade, France. AD - Univ La Rochelle, Mol Core Facil, Lab LIENSs, CNRS,UMR7266, F-17000 La Rochelle, France. UR - https://doi.org/10.1016/j.jff.2015.04.050 DO - 10.1016/j.jff.2015.04.050 KW - Bioactive peptides KW - Obesity KW - Human white pre-adipocytes' KW - Proliferation KW - Differentiation KW - Adipocyte differentiation markers N2 - The effect of 11 marine-derived cryptides was investigated on proliferation, differentiation and maturation of human white pre-adipocytes (HWP). They were all formerly identified as potent Angiotensin-Converting-Enzyme inhibitors.Val-Trp (VW),Val-Tyr (VY), Lys-Tyr (KY), Lys-Trp (KW), Ile-Tyr (IY), Ala-Pro (AP),Val-Ile-Tyr (VIY), Leu-Lys-Pro (LKP), Gly-Pro-Leu (GPL), Ala-Lys-Lys (AKK) and Val-Ala-Pro (VAP) were previously found in fish products and coproducts as well as other marine resources like wakame. Treatment with AP, VAP and AKK greatly affected viability of HWP during the proliferation period while KW and VW treatment reduced the number of viable cells during the differentiation stage. A GPL and IY incubation during the differentiation stage allowed the decrease of their final lipid content, of the GPDH activity and of the mRNA level of adipocyte markers (aP2, GLUT4, LPL and AGT). Moreover, a down regulation of both PPARγ and C/EBPα expression, two key regulators of adipogenesis,was observed.These findings indicate that small bioactive peptides from marine protein hydrolysates can target adipogenesis and thus could regulate energy metabolism disorders Y1 - 2015/08 PB - Elsevier Science Bv JF - Journal Of Functional Foods SN - 1756-4646 VL - 17 SP - 1 EP - 10 ID - 38014 ER -