FN Archimer Export Format
PT J
TI Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions
BT 
AF BEN HENDA, Yesmine
   LAAMARI, Mariem
   LANNELUC, Isabelle
   TRAVERS, Marie-Agnes
   AGOGUE, Helene
   ARNAUDIN, Ingrid
   BRIDIAU, Nicolas
   MAUGARD, Thierry
   PIOT, Jean-Marie
   SANNIER, Frederic
   BORDENAVE-JUCHEREAU, Stephanie
AS 1:1;2:1;3:1;4:2;5:3;6:1;7:1;8:1;9:1;10:1;11:1;
FF 1:;2:;3:;4:PDG-RBE-SG2M-LGPMM;5:;6:;7:;8:;9:;10:;11:;
C1 Univ La Rochelle, UFR Sci Technol Sante, Lab LIENSs, CNRS,UMR 7266,Approches Mol,Environm Sante, F-17042 La Rochelle 1, France.
   IFREMER, SG2M LGPMM, Lab Genet & Pathol Mollusques Marins, F-17390 La Tremblade, France.
   Univ La Rochelle, Mol Core Facil, Lab LIENSs, CNRS,UMR7266, F-17000 La Rochelle, France.
C2 UNIV LA ROCHELLE, FRANCE
   IFREMER, FRANCE
   CNRS, FRANCE
SI LA TREMBLADE
SE PDG-RBE-SG2M-LGPMM
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.973
TC 15
UR https://archimer.ifremer.fr/doc/00269/38014/36308.pdf
LA English
DT Article
DE ;Bioactive peptides;Obesity;Human white pre-adipocytes';Proliferation;Differentiation;Adipocyte differentiation markers
AB The effect of 11 marine-derived cryptides was investigated on proliferation, differentiation and maturation of human white pre-adipocytes (HWP). They were all formerly identified as potent Angiotensin-Converting-Enzyme inhibitors.Val-Trp (VW),Val-Tyr (VY), Lys-Tyr (KY), Lys-Trp (KW), Ile-Tyr (IY), Ala-Pro (AP),Val-Ile-Tyr (VIY), Leu-Lys-Pro (LKP), Gly-Pro-Leu (GPL), Ala-Lys-Lys (AKK) and Val-Ala-Pro (VAP) were previously found in fish products and coproducts as well as other marine resources like wakame. Treatment with AP, VAP and AKK greatly affected viability of HWP during the proliferation period while KW and VW treatment reduced the number of viable cells during the differentiation stage. A GPL and IY incubation during the differentiation stage allowed the decrease of their final lipid content, of the GPDH activity and of the mRNA level of adipocyte markers (aP2, GLUT4, LPL and AGT). Moreover, a down regulation of both PPARγ and C/EBPα expression, two key regulators of adipogenesis,was observed.These findings indicate that small bioactive peptides from marine protein hydrolysates can target adipogenesis and thus could regulate energy metabolism disorders
PY 2015
PD AUG
SO Journal Of Functional Foods
SN 1756-4646
PU Elsevier Science Bv
VL 17
UT 000360253300001
BP 1
EP 10
DI 10.1016/j.jff.2015.04.050
ID 38014
ER

EF