FN Archimer Export Format PT J TI Pesticides and Ostreid Herpesvirus 1 Infection in the Pacific Oyster, Crassostrea gigas BT AF MOREAU, Pierrick FAURY, Nicole BURGEOT, Thierry RENAULT, Tristan AS 1:1,3;2:1;3:2;4:1; FF 1:PDG-RBE-SG2M-LGPMM;2:PDG-RBE-SG2M-LGPMM;3:PDG-RBE-BE;4:PDG-RBE; C1 Ifremer Inst Francais Rech Exploitat Mer, Unite Sante Genet & Microbiol Mollusques, Lab Genet & Pathol Mollusques Marins, F-17390 Ronce Les Bains, La Tremblade, France. Ifremer Inst Francais Rech Exploitat Mer, Ifremer Res Unit Biogeochem & Ecotoxicol, F-44311 Nantes, France. Inst Pasteur, Unite Hepacivirus & Immunite Innee, Paris, France. C2 IFREMER, FRANCE IFREMER, FRANCE INST PASTEUR, FRANCE SI LA TREMBLADE NANTES SE PDG-RBE-SG2M-LGPMM PDG-RBE-BE PDG-RBE IN WOS Ifremer jusqu'en 2018 copubli-france IF 3.057 TC 13 UR https://archimer.ifremer.fr/doc/00273/38405/36730.pdf LA English DT Article AB Since 2008, mass mortality outbreaks have been reported in all French regions producing Pacific oysters, and in several Member States of the European Union. These mass mortality events of Pacific oysters are related to OsHV-1 infection. They occur during spring and summer periods leaving suspect the quality of the marine environment and the role of seasonal use of pesticides associated with the arrival of freshwater in oyster rearing areas. Pesticides have been also detected in French coastal waters, especially in areas of oyster production. Using PMA real-time PCR we showed that a mixture of 14 pesticides has no effect on the integrity of virus capsids from viral suspension in the conditions tested. A contact of oysters with this pesticide mixture was related to higher mortality rates among experimentally infected animals in comparison with control ones (no previous pesticide exposure before experimental infection). We therefore suggest that pesticides at realistic concentration can exert adverse effects on Pacific oysters and causes an increased susceptibility to the viral infection in experimental conditions. PY 2015 PD JUL SO Plos One SN 1932-6203 PU Public Library Science VL 10 IS 6 UT 000356932500113 DI 10.1371/journal.pone.0130628 ID 38405 ER EF