FN Archimer Export Format PT J TI Tulane Virus as a Potential Surrogate To Mimic Norovirus Behavior in Oysters BT AF DROUAZ, Najoua SCHAEFFER, Julien FARKAS, Tibor LE PENDU, Jacques LE GUYADER, Soizick AS 1:1;2:1;3:2;4:3;5:1; FF 1:PDG-RBE-SG2M-LSEM;2:PDG-RBE-SG2M-LSEM;3:;4:;5:PDG-RBE-SG2M-LSEM; C1 IFREMER, Lab Microbiol, LSEM SG2M, Nantes, France. Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Lab Specialized Clin Studies, Cincinnati, OH 45229 USA. Univ Nantes, INSERM, CNRS, U892,UMR6299, Nantes, France. C2 IFREMER, FRANCE CINCINNATI CHILDRENS HOSP MED CTR, USA UNIV NANTES, FRANCE SI NANTES SE PDG-RBE-SG2M-LSEM IN WOS Ifremer jusqu'en 2018 copubli-france copubli-univ-france copubli-int-hors-europe IF 3.823 TC 31 UR https://archimer.ifremer.fr/doc/00275/38633/37163.pdf https://archimer.ifremer.fr/doc/00275/38633/71643.pdf LA English DT Article AB Oyster contamination by noroviruses is an important health and economic problem. The present study aimed to compare the behaviors of Norwalk virus (the prototype genogroup I norovirus) and two culturable viruses: Tulane virus and mengovirus. After bioaccumulation, tissue distributions were quite similar for Norwalk virus and Tulane virus, with the majority of viral particles detected in digestive tissues, while mengovirus was detected in large amounts in the gills and mantle as well as in digestive tissues. The levels of persistence of all three viruses over 8 days were comparable, but clear differences were observed over longer periods, with Norwalk and Tulane viruses displaying rather similar half-lives, unlike mengovirus, which was cleared more rapidly. These results indicate that Tulane virus may be a good surrogate for studying norovirus behavior in oysters, and they confirm the prolonged persistence of Norwalk virus in oyster tissues. PY 2015 PD AUG SO Applied And Environmental Microbiology SN 0099-2240 PU Amer Soc Microbiology VL 81 IS 15 UT 000357668600038 BP 5249 EP 5256 DI 10.1128/AEM.01067-15 ID 38633 ER EF