FN Archimer Export Format
PT J
TI Energy and Antioxidant Responses of Pacific Oyster Exposed to Trace Levels of Pesticides
BT 
AF EPELBOIN, Yanouk
   QUERE, Claudie
   PERNET, Fabrice
   PICHEREAU, Vianney
   CORPOREAU, Charlotte
AS 1:1;2:1;3:1;4:2;5:1;
FF 1:PDG-RBE-PFOM-PI;2:PDG-RBE-PFOM-PI;3:PDG-RBE-PFOM;4:;5:PDG-RBE-PFOM-PI;
C1 UBO, UMR 6539, CNRS, IFREMER,IRD,Lab Sci Environm Marin LEMAR, F-29280 Plouzane, France.
   Univ Brest, UMR 6539, UBO,Inst Univ Europeen Mer, CNRS,UBO,IRD,Ifremer,Lab Sci Environm Marin LEMAR, F-29280 Plouzane, France.
C2 IFREMER, FRANCE
   UBO, FRANCE
SI BREST
SE PDG-RBE-PFOM-PI
   PDG-RBE-PFOM
UM LEMAR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.025
TC 16
UR https://archimer.ifremer.fr/doc/00284/39490/44227.pdf
LA English
DT Article
AB Here, we assess the physiological effects induced by environmental concentrations of pesticides in Pacific oyster Crassostrea gigas. Oysters were exposed for 14 d to trace levels of metconazole (0.2 and 2 mu g/L), isoproturon (0.1 and 1 mu g/L), or both in a mixture (0.2 and 0.1 mu g/L, respectively). Exposure to trace levels of pesticides had no effect on the filtration rate, growth, and energy reserves of oysters. However, oysters exposed to metconazole and isoproturon showed an overactivation of the sensing-kinase AMP-activated protein kinase alpha (AMPK alpha), a key enzyme involved in energy metabolism and more particularly glycolysis. In the meantime, these exposed oysters showed a decrease in hexokinase and pyruvate kinase activities, whereas 2-DE proteomic revealed that fructose-1,6-bisphosphatase (F-1,6-BP), a key enzyme of gluconeogenesis, was upregulated. Activities of antioxidant enzymes were higher in oysters exposed to the highest pesticide concentrations. Both pesticides enhanced the superoxide dismutase activity of oysters. Isoproturon enhanced catalase activity, and metconazole enhanced peroxiredoxin activity. Overall, our results show that environmental concentrations of metconazole or isoproturon induced subtle changes in the energy and antioxidant metabolisms of oysters.
PY 2015
PD SEP
SO Chemical Research In Toxicology
SN 0893-228X
PU Amer Chemical Soc
VL 28
IS 9
UT 000361865300020
BP 1831
EP 1841
DI 10.1021/acs.chemrestox.5b00269
ID 39490
ER

EF