FN Archimer Export Format
PT J
TI Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis
BT 
AF BOUVARD, Claire
   GALY-FAUROUX, Isabelle
   GRELAC, Francoise
   CARPENTIER, Wassila
   LOKAJCZYK, Anna
   GANDRILLE, Sophie
   COLLIEC-JOUAULT, Sylvia
   FISCHER, Anne-Marie
   HELLEY, Dominique
AS 1:1,2,3;2:2,4;3:1,2;4:5;5:2,6;6:2,6,7;7:8;8:2,4,7;9:2,4,7;
FF 1:;2:;3:;4:;5:;6:;7:PDG-RBE-BRM-LEMMMB;8:;9:;
C1 INSERM, UMR S765, F-75006 Paris, France.
   Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France.
   Univ Paris Diderot, Sorbonne Paris Cite, F-75013 Paris, France.
   INSERM, UMR S970, F-75015 Paris, France.
   Univ Paris 04, Plateforme P3S, F-75013 Paris, France.
   INSERM, UMR S1140, F-75006 Paris, France.
   Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France.
   IFREMER, F-44300 Nantes, France.
C2 INSERM, FRANCE
   UNIV PARIS 05, FRANCE
   UNIV PARIS 07, FRANCE
   INSERM, FRANCE
   UNIV PARIS 04, FRANCE
   INSERM, FRANCE
   HOP EUROPEEN GEORGES POMPIDOU, FRANCE
   IFREMER, FRANCE
SI NANTES
SE PDG-RBE-BRM-LEMMMB
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
   copubli-univ-france
IF 3.345
TC 27
UR https://archimer.ifremer.fr/doc/00308/41913/41187.pdf
LA English
DT Article
DE ;fucoidan;angiogenesis;vasculogenesis;migration;signaling;transcriptomics
AB Low-molecular-weight fucoidan (LMWF) is a sulfated polysaccharide extracted from brown seaweed that presents antithrombotic and pro-angiogenic properties. However, its mechanism of action is not well-characterized. Here, we studied the effects of LMWF on cell signaling and whole genome expression in human umbilical vein endothelial cells and endothelial colony forming cells. We observed that LMWF and vascular endothelial growth factor had synergistic effects on cell signaling, and more interestingly that LMWF by itself, in the absence of other growth factors, was able to trigger the activation of the PI3K/AKT pathway, which plays a crucial role in angiogenesis and vasculogenesis. We also observed that the effects of LMWF on cell migration were PI3K/AKT-dependent and that LMWF modulated the expression of genes involved at different levels of the neovessel formation process, such as cell migration and cytoskeleton organization, cell mobilization and homing. This provides a better understanding of LMWF's mechanism of action and confirms that it could be an interesting therapeutic approach for vascular repair.
PY 2015
PD DEC
SO Marine Drugs
SN 1660-3397
PU Mdpi Ag
VL 13
IS 12
UT 000367049700021
BP 7446
EP 7462
DI 10.3390/md13127075
ID 41913
ER

EF