FN Archimer Export Format
PT J
TI DNA damage in dab (Limanda limanda) and haddock (Melanogrammus aeglefinus) from European seas
BT 
AF HYLLAND, Ketil
   SKEI, Bjorn Borge
   BRUNBORG, Gunnar
   LANG, Thomas
   GUBBINS, Matthew J.
   LE GOFF, Jeremie
   BURGEOT, Thierry
AS 1:1;2:1;3:2;4:3;5:4;6:5;7:6;
FF 1:;2:;3:;4:;5:;6:;7:PDG-RBE-BE;
C1 Univ Oslo, Dept Biosci, POB 1066, N-0316 Oslo, Norway.
   Natl Inst Publ Hlth, POB 4404 Nydalen, N-0403 Oslo, Norway.
   Thunen Inst Fisheries Ecol, Deichstr 12, D-27472 Cuxhaven, Germany.
   Marine Scotland Sci, Marine Lab, 375 Victoria Rd, Aberdeen AB11 9DB, Scotland.
   Ctr Francois Baclesse, AdnTox, GRECAN, Ave Gen Harris, F-14076 Caen 05, France.
   IFREMER, Lab Ecotoxicol, Rue Ile Yeu,BP 21105, F-44311 Nantes 03, France.
C2 UNIV OSLO, NORWAY
   NATL INST PUBL HLTH, NORWAY
   THUNEN INST FISHERIES ECOL, GERMANY
   MARINE SCOTLAND SCI (NRL), UK
   GRECAN, FRANCE
   IFREMER, FRANCE
SI NANTES
SE PDG-RBE-BE
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-europe
IF 3.159
TC 15
UR https://archimer.ifremer.fr/doc/00309/42064/44971.pdf
LA English
DT Article
DE ;ICON;Comet;DNA adducts;Genotoxicity;Haddock;Dab;European seas
AB Dab (Limanda limanda) and haddock (Melanogrammus aeglefinus) were collected from coastal and offshore locations in the Baltic (dab only), North Sea (haddock from one location only) and Iceland. Blood was analysed for DNA strand breaks using the comet assay and liver samples for DNA adduct concentrations. DNA strand breaks were at background levels in dab from the two Iceland locations and from the Dogger Bank. The highest levels were observed in dab from the Firth of Forth, Ekofisk and the German Bight. Hepatic DNA adducts in dab were highest at Ekofisk, in the Baltic and Dogger Bank, below detection limit in dab from Iceland and low in dab from the Firth of Forth and German Bight. There was large variation in DNA strand breaks between locations and individuals for haddock, particularly from Iceland. Adduct concentrations were elevated in haddock from both Iceland and the Firth of Forth. A general linear model (GLM) suggested that, in addition to location, the size of dab and its general condition contributed to explaining the observed variability in DNA strand breaks. A GLM for adducts in dab similarly allocated most of the variability to location, but with a possible contribution from CYP1A activity. There were no apparent differences between male and female dab for any of the methods. There was no obvious relationship between strand breaks and adducts in the same fish although dab from Ekofisk and Iceland had respectively high and low responses using both methods. The results from this large-scale study showed pollution-related genotoxicity for dab, that fish blood samples can be conserved prior to comet analyses and that there are clear species differences in genotoxic responses even when collected at the same location.
PY 2017
PD MAR
SO Marine Environmental Research
SN 0141-1136
PU Elsevier Sci Ltd
VL 124
UT 000392678200008
BP 54
EP 60
DI 10.1016/j.marenvres.2016.01.001
ID 42064
ER

EF