FN Archimer Export Format
PT J
TI Differentiation of gonyautoxins by ion mobility - mass spectrometry; a cationization study
BT 
AF POYER, Salome
   LOUTELIER-BOURHIS, Corinne
   TOGNETTI, Vincent
   JOUBERT, Laurent
   ENCHE, Julien
   BOSSEE, Anne
   MONDEGUER, Florence
   HESS, Philipp
   AFONSO, Carlos
AS 1:1,2;2:1,2;3:1,2;4:1,2;5:4;6:4;7:3;8:3;9:1,2;
FF 1:;2:;3:;4:;5:;6:;7:PDG-ODE-DYNECO-PHYC;8:PDG-ODE-DYNECO-PHYC;9:;
C1 Normandie Univ, COBRA, UMR 6014, 1 Rue Tesniere, F-76821 Mont St Aignan, France.
   Univ Rouen, INSA Rouen, CNRS, FR 3038,IRCOF, 1 Rue Tesniere, F-76821 Mont St Aignan, France.
   IFREMER, Lab Phycotoxines, F-44311 Nantes 03, France.
   DGA Maitrise NRBC, Dept Anal Chim, F-91710 Vert Le Petit, France.
C2 UNIV ROUEN, FRANCE
   UNIV ROUEN, FRANCE
   IFREMER, FRANCE
   DGA MAITRISE NRBC, FRANCE
SI NANTES
SE PDG-ODE-DYNECO-PHYC
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 1.702
TC 8
UR https://archimer.ifremer.fr/doc/00317/42863/42291.pdf
LA English
DT Article
DE ;Ion mobility;Gonyautoxin;Collision cross-section;Alkali adduct
AB Gonyautoxins are potent natural neurotoxic analogues of saxitoxin. Due to their biological activity and submilligram lethal dose for man, fast and efficient methods are required for their characterization. Recent advances in ion mobility-mass spectrometry (IM-MS) showed that differentiation of isomers could be achieved using specific experimental conditions involving particular buffer gases as well as cationic species. In this work, IM-MS experiments were carried out using alkali metal ions (Met = Li+, Na+ or K+) and different buffer gases (N2, N2O and CO2) to improve the differentiation of gonyautoxin isomers. The separation of [GTX + Met]+ ion was achieved for GTX2/3 and GTX1/4 from their Na or K adducts. For dcGTX2/3, the ion mobility separation can only be obtained with peak to peak resolution (Rp-p) close to 1 from the [GTXs + Met − H2O]+ species. To understand the gas phase conformation of the different diastereomers, density functional theory (DFT) calculations were performed. IM separation, and collision cross sections on [GTXs + Met]+ and [GTXs + Met − H2O]+ are reported for the first time.
PY 2016
PD MAY
SO International Journal Of Mass Spectrometry
SN 1387-3806
PU Elsevier Science Bv
VL 402
UT 000376544900003
BP 20
EP 28
DI 10.1016/j.ijms.2016.02.013
ID 42863
ER

EF