Detection of Hepatitis E Virus in Sewage After an Outbreak on a French Island

Type Article
Date 2016-09
Language English
Author(s) Miura Takayuki1, 6, Lhomme Sebastien2, Le Saux Jean-Claude1, Le Mehaute Philippe3, Guillois Yvonnick4, Couturier Elizabeth5, Izopet Jacques2, Abranavel Florence2, Le Guyader Soizick1
Affiliation(s) 1 : IFREMER, Lab Microbiol, LSEM SG2M, BP 21105, F-44311 Nantes 03, France.
2 : Ctr Hosp Univ, Natl Reference Ctr HEV, Toulouse, France.
3 : SAUR, Direct Gen Ouest, Vannes, France.
4 : Inst Veille Sanit, Reg Epidemiol Unit Brittany Reg, Rennes, France.
5 : Inst Veille Sanit, Dept Infect Dis, St Maurice, France.
6 : Tohoku Univ, New Ind Creat Hatchery Ctr NICHe, Aoba Ku, 6-6-04 Aoba, Sendai, Miyagi 9808579, Japan.
Source Food And Environmental Virology (1867-0334) (Springer), 2016-09 , Vol. 8 , N. 3 , P. 194-199
DOI 10.1007/s12560-016-9241-9
WOS© Times Cited 32
Keyword(s) Hepatitis E virus, Wastewater treatment plant, Quantification
Abstract A hepatitis E outbreak, which occurred on a small isolated island, provided an opportunity to evaluate the association between the number of hepatitis E cases in the community and the concentration of virus detected in sewage. Samples were collected from the different sewage treatment plants from the island and analyzed for the presence of hepatitis E (HEV) virus using real-time RT-PCR. We demonstrated that if 1–4 % of inhabitants connected to a WWTP were infected with HEV, raw sewage contained HEV at detectable levels. The finding that such a small number of infected people can contaminate municipal sewage works raises the potential of the further distribution of the virus. Indeed, investigating the routes of transmission of HEV, including the potential for sewage effluent to contain infectious HEV, may help us to better understand the epidemiology of this pathogen, which is considered to be an emerging concern in Europe
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Miura Takayuki, Lhomme Sebastien, Le Saux Jean-Claude, Le Mehaute Philippe, Guillois Yvonnick, Couturier Elizabeth, Izopet Jacques, Abranavel Florence, Le Guyader Soizick (2016). Detection of Hepatitis E Virus in Sewage After an Outbreak on a French Island. Food And Environmental Virology, 8(3), 194-199. Publisher's official version : , Open Access version :