FN Archimer Export Format
PT J
TI Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda)
BT 
AF DESTOUMIEUX, Delphine
   BULET, Philippe
   LOEW, Damarys
   VAN DORSSELAER, Alain
   RODRIGUEZ, Jenny
   BACHERE, Evelyne
AS 1:1,2;2:3;3:4;4:4;5:5;6:1,2;
FF 1:;2:;3:;4:;5:;6:;
C1 IFREMER, FRANCE
   UNIV MONTPELLIER 2, IFREMER, CNRS, F-34095 MONTPELLIER, FRANCE.
   INST BIOL MOL & CELLULAIRE, CNRS, UPR REPONSE IMMUNITAIRE & DEV CHEZ INSECTES 9022, F-67084 STRASBOURG, FRANCE.
   UNIV STRASBOURG 1, LAB SPECTROMETRIE MASSE BIOORGAN,URA 31,CNRS, FAC CHIM, F-67008 STRASBOURG, FRANCE.
   ESCUELA SUPER POLITECN LITORAL, CTR NACL ACUICULTURE & INVEST MARINAS, GUAYAQUIL, ECUADOR.
C2 IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   CNRS, FRANCE
   UNIV STRASBOURG, FRANCE
   CENAIM, ECUADOR
IN WOS Ifremer jusqu'en 2018
IF 7.368
TC 353
UR https://archimer.ifremer.fr/doc/00335/44649/57344.pdf
LA English
DT Article
AB We report here the isolation of three members of a new family of antimicrobial peptides from the hemolymph of shrimps Penaeus vannamei in which immune response has not been experimentally induced. The three molecules display antimicrobial activity against fungi and bacteria with a predominant activity against Gram-positive bacteria. The complete sequences of these peptides were determined by a combination of enzymatic cleavages, Edman degradation, mass spectrometry, and cDNA cloning using a hemocyte cDNA library. The mature molecules (50 and 62 residues) are characterized by an NH2-terminal domain rich in proline residues and a COOH-terminal domain containing three intramolecular disulfide bridges. One of these molecules is post-translationally modified by a pyroglutamic acid at the first position. Comparison of the data obtained from the cDNA clones and mass spectrometry showed that two of these peptides are probably COOH-terminally amidated by elimination of a glycine residue. These molecules with no evident homology to other hitherto described antimicrobial peptides were named penaeidins. 
PY 1997
PD NOV
SO Journal Of Biological Chemistry
SN 0021-9258
PU Amer Soc Biochemistry Molecular Biology Inc
VL 272
IS 45
UT A1997YF21900038
BP 28398
EP 28406
DI 10.1074/jbc.272.45.28398
ID 44649
ER

EF