FN Archimer Export Format
PT J
TI Toxicity assessment of water-accommodated fractions from two different oils using a zebrafish (Danio rerio) embryo-larval bioassay with a multilevel approach
BT 
AF PERRICHON, Prescilla
   LE MENACH, Karyn
   AKCHA, Farida
   CACHOT, Jerome
   BUDZINSKI, Helene
   BUSTAMANTE, Paco
AS 1:1,2;2:3;3:1;4:3;5:3;6:2;
FF 1:PDG-RBE-BE;2:;3:PDG-RBE-BE-LBEX;4:;5:;6:;
C1 IFREMER, Lab Biogeochim & Ecotoxicol, Lhoumeau Nantes, France.
   Univ La Rochelle, CNRS, Littoral Environm & Soc LIENSs, UMRi 7266, 2 Rue Olympe Gouges, F-17042 La Rochelle 01, France.
   Univ Bordeaux, UMR EPOC CNRS 5805, Ave Fac, F-33405 Talence, France.
C2 IFREMER, FRANCE
   UNIV LA ROCHELLE, FRANCE
   UNIV BORDEAUX, FRANCE
SI LA ROCHELLE
   NANTES
SE PDG-RBE-BE
   PDG-RBE-BE-LBEX
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 4.9
TC 48
UR https://archimer.ifremer.fr/doc/00342/45324/46430.pdf
LA English
DT Article
DE ;Zebrafish embryos;Oil exposure;Teratogenicity;Swimming performance;Bradycardia;Detoxification pathway
AB Petroleum compounds from chronic discharges and oil spills represent an important source of environmental pollution. To better understand the deleterious effects of these compounds, the toxicity of water-accommodated fractions (WAF) from two different oils (brut Arabian Light and Erika heavy fuel oils) were used in this study. Zebrafish embryos (Danio rerio) were exposed during 96 h at three WAF concentrations (1, 10 and 100% for Arabian Light and 10, 50 and 100% for Erika) in order to cover a wide range of polycyclic aromatic hydrocarbon (PAH) concentrations, representative of the levels found after environmental oil spills. Several endpoints were recorded at different levels of biological organization, including lethal endpoints, morphological abnormalities, photomotor behavioral responses, cardiac activity, DNA damage and exposure level measurements (EROD activity, cyp1a and PAH metabolites). Neither morphological nor behavioral or physiological alterations were observed after exposure to Arabian Light fractions. In contrast, the Erika fractions led a high degree of toxicity in early life stages of zebrafish. Despite of defense mechanisms induced by oil, acute toxic effects have been recorded including mortality, delayed hatching, high rates of developmental abnormalities, disrupted locomotor activity and cardiac failures at the highest PAH concentrations (∑ TPAHs = 257,029 ± 47,231 ng·L− 1). Such differences in toxicity are likely related to the oil composition. The use of developing zebrafish is a good tool to identify wide range of detrimental effects and elucidate their underlying foundations. Our work highlights once more, the cardiotoxic action (and potentially neurotoxic) of petroleum-related PAHs.
PY 2016
PD OCT
SO Science Of The Total Environment
SN 0048-9697
PU Elsevier Science Bv
VL 568
UT 000382258300096
BP 952
EP 966
DI 10.1016/j.scitotenv.2016.04.186
ID 45324
ER

EF