TY - JOUR T1 - Integrated monitoring of chemicals and their effects on four sentinel species, Limanda limanda, Platichthys flesus, Nucella lapillus and Mytilus sp, in Seine Bay: A key step towards applying biological effects to monitoring A1 - Burgeot,Thierry A1 - Akcha,Farida A1 - Menard,Dominique A1 - Robinson,Craig A1 - Loizeau,Veronique A1 - Brach-Papa,Christophe A1 - Martinez-Gomez,Concepcion A1 - Le Goff,Jeremie A1 - Budzinski,Helene A1 - Le Menach,Karine A1 - Cachot,Jerome A1 - Minier,Christophe A1 - Broeg,Katja A1 - Hylland,Ketil AD - IFREMER, Dept Biogeochem & Ecotoxicol, Rue Ile Yeu,BP 21105, F-44311 Nantes 03, France. AD - Marine Lab, Marine Scotland Sci, 375 Victoria Rd, Aberdeen AB11 9DB, Scotland. AD - Inst Espagriol Oceanog, Oceanog Ctr Murcia, Varadero 1, Murcia 30740, Spain. AD - AdnTox, Ctr Francois Baclesse, GRECAN, Ave Gen Harris, F-14076 Caen 05, France. AD - Univ Bordeaux, Lab EPOC, UMR CNRS 5805, F-33615 Pessac, France. AD - Univ Havre, UMR SEBIO, Lab Ecotoxicol LEMA, 25 Rue P Lebon, F-76058 Le Havre, France. AD - Fed Maritime & Hydrog Agcy Germany BSH, Benhard Nocht Str 78, D-20359 Hamburg, Germany. AD - Univ Oslo, Dept Biosci, Pb 1066, N-0316 Oslo, Norway. UR - https://doi.org/10.1016/j.marenvres.2016.10.009 DO - 10.1016/j.marenvres.2016.10.009 KW - Biomarkers KW - Bioassays KW - Chemical contamination KW - Integrated monitoring in chemistry and biology KW - Local study KW - Large geographical scale N2 - The International workshop on Integrated Assessment of CONtaminants impacts on the North sea (ICON) provided a framework to validate the application of chemical and biological interpretation thresholds (BACs and EACs) in the Seine Bay in France. Bioassays (oyster larval anomalies, Corophium arenarium toxicity assay and DR Calux) for sediment and biomarkers: ethoxyresorufin-O-deethylase (EROD) activity, acetylcholinesterase (AChE) activity, lysosomal membrane stability (LMS), DNA strand breaks using the comet assay, DNA adducts, micronucleus (MN), PAH metabolites, intersex and fish external pathologies were analyzed in four marine sentinel species (Platichthys flesus, Limanda limanda, Mytilus sp. and Nucella lapilus). Polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and heavy metals were analyzed in biota and sediment. Results for sediment and four species in 2008–2009 made it possible to quantify the impact of contaminants using thresholds (Environmental Assessment Criteria/EAC2008: 70% and EAC2009: 60%) and effects (EAC2008: 50% and EAC2009: 40%) in the Seine estuary. The Seine estuary is ranked among Europe's most highly polluted sites. Y1 - 2017/03 PB - Elsevier Sci Ltd JF - Marine Environmental Research SN - 0141-1136 VL - 124 SP - 92 EP - 105 ID - 46789 ER -