FN Archimer Export Format PT J TI Integrated monitoring of chemicals and their effects on four sentinel species, Limanda limanda, Platichthys flesus, Nucella lapillus and Mytilus sp, in Seine Bay: A key step towards applying biological effects to monitoring BT AF BURGEOT, Thierry AKCHA, Farida MENARD, Dominique ROBINSON, Craig LOIZEAU, Veronique BRACH-PAPA, Christophe MARTINEZ-GOMEZ, Concepcion LE GOFF, Jeremie BUDZINSKI, Helene LE MENACH, Karine CACHOT, Jerome MINIER, Christophe BROEG, Katja HYLLAND, Ketil AS 1:1;2:1;3:1;4:2;5:1;6:1;7:3;8:4;9:5;10:5;11:5;12:6;13:7;14:8; FF 1:PDG-RBE-BE;2:PDG-RBE-BE-LBEX;3:PDG-RBE-BE-LBEX;4:;5:PDG-RBE-BE-LBCO;6:PDG-ODE-LITTORAL-LERPAC;7:;8:;9:;10:;11:;12:;13:;14:; C1 IFREMER, Dept Biogeochem & Ecotoxicol, Rue Ile Yeu,BP 21105, F-44311 Nantes 03, France. Marine Lab, Marine Scotland Sci, 375 Victoria Rd, Aberdeen AB11 9DB, Scotland. Inst Espagriol Oceanog, Oceanog Ctr Murcia, Varadero 1, Murcia 30740, Spain. AdnTox, Ctr Francois Baclesse, GRECAN, Ave Gen Harris, F-14076 Caen 05, France. Univ Bordeaux, Lab EPOC, UMR CNRS 5805, F-33615 Pessac, France. Univ Havre, UMR SEBIO, Lab Ecotoxicol LEMA, 25 Rue P Lebon, F-76058 Le Havre, France. Fed Maritime & Hydrog Agcy Germany BSH, Benhard Nocht Str 78, D-20359 Hamburg, Germany. Univ Oslo, Dept Biosci, Pb 1066, N-0316 Oslo, Norway. C2 IFREMER, FRANCE MARINE SCOTLAND SCI (NRL), UK IEO, SPAIN GRECAN, FRANCE UNIV BORDEAUX, FRANCE UNIV LE HAVRE, FRANCE BSH, GERMANY UNIV OSLO, NORWAY SI NANTES BREST TOULON SE PDG-RBE-BE PDG-RBE-BE-LBEX PDG-RBE-BE-LBCO PDG-ODE-LITTORAL-LERPAC IN WOS Ifremer jusqu'en 2018 copubli-france copubli-europe copubli-univ-france IF 3.159 TC 23 UR https://archimer.ifremer.fr/doc/00357/46789/46655.pdf LA English DT Article DE ;Biomarkers;Bioassays;Chemical contamination;Integrated monitoring in chemistry and biology;Local study;Large geographical scale AB The International workshop on Integrated Assessment of CONtaminants impacts on the North sea (ICON) provided a framework to validate the application of chemical and biological interpretation thresholds (BACs and EACs) in the Seine Bay in France. Bioassays (oyster larval anomalies, Corophium arenarium toxicity assay and DR Calux) for sediment and biomarkers: ethoxyresorufin-O-deethylase (EROD) activity, acetylcholinesterase (AChE) activity, lysosomal membrane stability (LMS), DNA strand breaks using the comet assay, DNA adducts, micronucleus (MN), PAH metabolites, intersex and fish external pathologies were analyzed in four marine sentinel species (Platichthys flesus, Limanda limanda, Mytilus sp. and Nucella lapilus). Polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and heavy metals were analyzed in biota and sediment. Results for sediment and four species in 2008–2009 made it possible to quantify the impact of contaminants using thresholds (Environmental Assessment Criteria/EAC2008: 70% and EAC2009: 60%) and effects (EAC2008: 50% and EAC2009: 40%) in the Seine estuary. The Seine estuary is ranked among Europe's most highly polluted sites. PY 2017 PD MAR SO Marine Environmental Research SN 0141-1136 PU Elsevier Sci Ltd VL 124 UT 000392678200012 BP 92 EP 105 DI 10.1016/j.marenvres.2016.10.009 ID 46789 ER EF