FN Archimer Export Format
PT J
TI Vibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition
BT 
AF BRUTO, Maxime
   JAMES, Adele
   PETTON, Bruno
   LABREUCHE, Yannick
   CHENIVESSE, Sabine
   ALUNNO-BRUSCIA, Marianne
   POLZ, Martin F.
   LE ROUX, Frederique
AS 1:1,2;2:1,2;3:1,3;4:1,2;5:2;6:1,3;7:4;8:1,2;
FF 1:PDG-RBE-PFOM;2:PDG-RBE-PFOM;3:PDG-RBE-PFOM-PI;4:PDG-RBE-PFOM;5:;6:PDG-RBE-PFOM-PI;7:;8:PDG-RBE-PFOM;
C1 Ifremer, Unite Physiol Fonct Organismes Marins, Plouzane, France.
   UPMC Paris 06, Sorbonne Univ, Integrat Biol Marine Models, CNRS,UMR 8227,Stn Biol Roscoff, Roscoff, France.
   Ifremer, LEMAR UMR 6539, 11 Presquile Vivier, Argenton En Landunvez, France.
   MIT, Parsons Lab Environm Sci & Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
C2 IFREMER, FRANCE
   UNIV PARIS 06, FRANCE
   IFREMER, FRANCE
   MIT, USA
SI ROSCOFF
   BREST
   ARGENTON
SE PDG-RBE-PFOM
   PDG-RBE-PFOM-PI
UM LEMAR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 9.52
TC 86
UR https://archimer.ifremer.fr/doc/00360/47137/49044.pdf
LA English
DT Article
AB Vibrios are frequently associated with oyster mortality; however whether they are the primary causative agent or secondary opportunistic colonizers is not well understood. Here we combine analysis of natural infection dynamics, population genomics and molecular genetics to ask (i) to what extent oysters are passively colonized by Vibrio population present in the surrounding water, (ii) how populations turn over during pathogenicity events and (iii) what genetic factors are responsible for pathogenicity. We identified several populations of Vibrio preferentially associated with oyster tissues. Among these, Vibrio crassostreae is particularly abundant in diseased animals while nearly absent in the surrounding water, and its pathogenicity is correlated with the presence of a large mobilizable plasmid. We further demonstrate that the plasmid is essential for killing but not necessary for survival in tissues of oysters. Our results suggest that V. crassostreae first differentiated into a benign oyster colonizer that was secondarily turned into a pathogen by introgression of a virulence plasmid into the population, possibly facilitated by elevated host density in farming areas.
PY 2017
PD APR
SO Isme Journal
SN 1751-7362
PU Nature Publishing Group
VL 11
IS 4
UT 000397281200020
BP 1043
EP 1052
DI 10.1038/ismej.2016.162
ID 47137
ER

EF