Lipophilic Toxin Profile in Mytilus galloprovincialis from the North Atlantic Coast of Morocco: LC-MS/MS and Mouse Bioassay Analyses
|Author(s)||Ben Haddouch Asia1, Amanhi Rachid1, Amzil Zouher2, Taleb Hamib1, Rovillon Georges-Augustin2, Adly Farida3, Loutfi Mohammed3|
|Affiliation(s)||1 : Quality andSafety Department of MarineEnvironment,NationalFisheries Research Institute(INRH), Bd Sidi Abderrahmane, Ouled Jmal, 20050 Casablanca, Morocco
2 : IFREMER-Phycotoxins Laboratory, BP 21105, F-44311 Nantes, France
3 : Laboratory Biochemistry and MolecularBiology, Faculty of Science Ain Chock, Km 8, Route d’El Jadida,BP, 5366, Maârif. Casablanca. Morocco
|Source||International Journal of Science and Research (IJSR) (2319-7064), 2017-02 , Vol. 6 , N. 2 , P. 186-|
|Note||Paper ID: 24121602|
|Keyword(s)||diarrheictoxins, lipophilic toxins, LC-MS/MS, mouse test, shellfish|
|Abstract||Forthe Moroccan Phycotoxins Monitoring that is part of theSafety of theCoastal Monitoring Network(RSSL),shellfish sampleswereharvestedfromdifferentlocations at NorthAtlantic of Morocco whereharmful algaeblooms were known to have occurred. Forallshellfishsamples found positive by themouse bioassay fordiarrheicshellfishpoisoning(DSP)toxins,liquid chromatography coupled to tandem massspectrometry(LC-MS-MS) in order to search thefollowinglipophilictoxins: okadaic acid (OA), dinophysistoxins(DTXs), pectenotoxins(PTXs), azaspiracids(AZAs), yessotoxins(YTXs), spirolides(SPXs) and gymnodimines (GYMs).Theresultsrevealeddifferentlipophilictoxinprofiles as a function of theshellfish sampling location.
It has beennoticed that allthesamples contained OA and its derivativesnamed dinophysistoxins(DTXs). In addition, other lipophilictoxinswerefound in shellfishsamples:(YTXs), and pectenotoxins(PTX-2, PTX-2-seco-acid and 7- epi-PTX-2-seco-acid) on theNorthAtlantic coast .This paper reports on thefirstdetection of YTXs,PTXsGYMs and their derivatives in Moroccan shellfish.