FN Archimer Export Format
PT J
TI Structure of an octameric form of the minichromosome maintenance protein from the archaeon Pyrococcus abyssi
BT 
AF CANNONE, Giuseppe
   VISENTIN, Silvia
   PALUD, Adeline
   HENNEKE, Ghislaine
   SPAGNOLO, Laura
AS 1:1,2,3;2:1,2,4;3:5,6,7;4:5,6,7;5:1;
FF 1:;2:;3:;4:PDG-REM-EEP-LMEE;5:;
C1 Univ Glasgow, Inst Mol Cell & Syst Biol, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland.
   Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, Scotland.
   Univ Edinburgh, Ctr Sci Extreme Condit, Edinburgh EH9 3JR, Midlothian, Scotland.
   Rutherford Appleton Labs, ISIS Neutron Source Sci & Technol Res Council, Harwell OX11 0QX, Berks, England.
   IFREMER, Lab Microbiol Environm Extremes, UMR 6197, Zi Pointe Diable CS 10070, F-29280 Plouzane, France.
   Univ Bretagne Occidentale, Lab Microbiol Environm Extremes, UMR 6197, Rue Dumont Urville, F-29280 Plouzane, France.
   CNRS, Lab Microbiol Environm Extremes, UMR 6197, Rue Dumont Urville, F-29280 Plouzane, France.
C2 UNIV GLASGOW, UK
   UNIV ABERDEEN, UK
   UNIV EDINBURGH, UK
   RUTHERFORD APPLETON LABS, UK
   IFREMER, FRANCE
   UBO, FRANCE
   CNRS, FRANCE
SI BREST
SE PDG-REM-EEP-LMEE
UM BEEP-LM2E
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
IF 4.122
TC 2
UR https://archimer.ifremer.fr/doc/00373/48434/48701.pdf
   https://archimer.ifremer.fr/doc/00373/48434/48702.pdf
LA English
DT Article
AB Cell division is a complex process that requires precise duplication of genetic material. Duplication is concerted by replisomes. The Minichromosome Maintenance (MCM) replicative helicase is a crucial component of replisomes. Eukaryotic and archaeal MCM proteins are highly conserved. In fact, archaeal MCMs are powerful tools for elucidating essential features of MCM function. However, while eukaryotic MCM2-7 is a heterocomplex made of different polypeptide chains, the MCM complexes of many Archaea form homohexamers from a single gene product. Moreover, some archaeal MCMs are polymorphic, and both hexameric and heptameric architectures have been reported for the same polypeptide. Here, we present the structure of the archaeal MCM helicase from Pyrococcus abyssi in its single octameric ring assembly. To our knowledge, this is the first report of a full-length octameric MCM helicase.
PY 2017
PD FEB
SO Scientific Reports
SN 2045-2322
PU Nature Publishing Group
VL 7
IS 42019
UT 000393551100001
BP 1
EP 10
DI 10.1038/srep42019
ID 48434
ER

EF