FN Archimer Export Format
PT J
TI Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures
BT 
AF VIGNET, Caroline
   TRENKEL, Verena
   VOUILLARMET, Annick
   BRICCA, Giampiero
   BEGOUT, Marie-Laure
   COUSIN, Xavier
AS 1:1;2:2;3:3;4:3;5:1;6:1,4,5;
FF 1:PDG-RBE-BE;2:PDG-RBE-EMH;3:;4:;5:PDG-RBE-HGS;6:;
C1 IFREMER, Lab Ressources Halieut, Pl Gaby Coll, F-17137 Lhoumeau, France.
   IFREMER, Unite Ecol & Modeles Halieut, BP 21105, F-44311 Nantes 03, France.
   Univ Lyon 1, Genom Fonct Hypertens Arterielle, EA 4173, 8 Ave Rockefeller, F-69373 Lyon 08, France.
   IFREMER, UMR MARBEC, Lab Adaptat & Adaptabilites Anim & Syst, Route Maguelone, F-34250 Palavas Les Flots, France.
   Univ Paris Saclay, INRA, GABI, AgroParisTech, F-78350 Jouy En Josas, France.
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV LYON, FRANCE
   IFREMER, FRANCE
   INRA, FRANCE
SI LA ROCHELLE
   NANTES
SE PDG-RBE-BE
   PDG-RBE-EMH
   PDG-RBE-HGS
UM MARBEC
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
   copubli-p187
   copubli-univ-france
IF 3.687
TC 22
UR https://archimer.ifremer.fr/doc/00375/48578/48900.pdf
LA English
DT Article
DE ;monoamine;polycyclic aromatic hydrocarbons;behaviour;anxiety;swimming activity;zebrafish
AB Zebrafish were exposed through diet to two environmentally relevant polycyclic aromatic hydrocarbons (PAHs) mixtures of contrasted compositions, one of pyrolytic (PY) origin and one from light crude oil (LO). Monoamine concentrations were quantified in the brains of the fish after six month of exposure. A significant decrease in noradrenaline (NA) was observed in fish exposed to both mixtures, while a decrease in serotonin (5HT) and dopamine (DA) was observed only in LO-exposed fish. A decrease in metabolites of 5HT and DA was observed in fish exposed to both mixtures. Several behavioural disruptions were observed that depended on mixtures, and parallels were made with changes in monoamine concentrations. Indeed, we observed an increase in anxiety in fish exposed to both mixtures, which could be related to the decrease in 5HT and/or NA, while disruptions of daily activity rhythms were observed in LO fish, which could be related to the decrease in DA. Taken together, these results showed that (i) chronic exposures to PAHs mixtures disrupted brain monoamine contents, which could underlie behavioural disruptions, and that (ii) the biological responses depended on mixture compositions
PY 2017
PD MAR
SO International Journal Of Molecular Sciences
SN 1422-0067
PU Mdpi Ag
VL 18
IS 3
UT 000396253700091
DI 10.3390/ijms18030560
ID 48578
ER

EF