Response of the pearl oyster Pinctada margaritifera to cadmium and chromium: Identification of molecular biomarkers

Type Article
Date 2017-05
Language English
Author(s) Gueguen YannickORCID1, Saulnier Denis1, Santini Adrien1, Magre Kevin1, Garen Pierre1, Bernagout Solene2, 3, Nohl Marine2, 3, Bouisset Patrick2, 3, Helme Herehia2, 3, Planes Serge4, Le Moullac GillesORCID1
Affiliation(s) 1 : UPF, IFREMER, ILM IRD, UMR EIO 241, Labex Corail,BP 49, F-98719 Tahiti, French Polynesi, France.
2 : Univ Montpellier, UPVD, CNRS, IFREMER,IHPE UMR 5244, CC 80, F-34095 Montpellier, France.
3 : IRSN LESE, BP 182, F-98725 Tahiti, French Polynesi, France.
4 : EPHE, CRIOBE, USR CNRS 3278, Labex Corail, Moorea, French Polynesi, France.
Source Marine Pollution Bulletin (0025-326X) (Pergamon-elsevier Science Ltd), 2017-05 , Vol. 118 , N. 1-2 , P. 420-426
DOI 10.1016/j.marpolbul.2017.03.012
WOS© Times Cited 10
Keyword(s) Pinctada margaritifera, French Polynesia, Cadmium, Chromium, Gene expression, Metallothionein
Abstract This study was designed to identify in the pearl oyster Pinctada margaritifera, used as a bio-accumulator, molecular biomarkers for the presence of heavy metals in the lagoon environment. Pearl oysters were exposed to 2 concentrations (1 and 10 μg L− 1) of cadmium (Cd) and chromium (Cr) compared to a control. Twelve target genes encoding proteins potentially involved in the response to heavy metal contamination with antioxidant, detoxification or apoptosis activities were selected. P. margaritifera accumulated Cd but not Cr, and mortality was related to the amount of Cd accumulated in tissues. In response to Cd-Cr contamination, metallothionein (MT) was significantly up-regulated by Cd-Cr at both concentrations, while 7 others (SOD, CAT, GPX, GSTO, GSTM, CASP, MDR) were down-regulated. Based on the development of these molecular tools, we propose that the pearl oyster, P. margaritifera, could be used as a sentinel species for heavy metal contamination in the lagoons of tropical ecosystems.
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Gueguen Yannick, Saulnier Denis, Santini Adrien, Magre Kevin, Garen Pierre, Bernagout Solene, Nohl Marine, Bouisset Patrick, Helme Herehia, Planes Serge, Le Moullac Gilles (2017). Response of the pearl oyster Pinctada margaritifera to cadmium and chromium: Identification of molecular biomarkers. Marine Pollution Bulletin, 118(1-2), 420-426. Publisher's official version : https://doi.org/10.1016/j.marpolbul.2017.03.012 , Open Access version : https://archimer.ifremer.fr/doc/00376/48707/