FN Archimer Export Format
PT J
TI Parental diuron-exposure alters offspring transcriptome and fitness in Pacific oyster Crassostrea gigas
BT 
AF BACHERE, Evelyne
   BARRANGER, Audrey
   BRUNO, Roman
   ROUXEL, Julien
   MENARD, Dominique
   PIQUEMAL, David
   AKCHA, Farida
AS 1:1;2:2;3:3;4:2;5:2;6:3,4;7:2;
FF 1:PDG-RBE-IHPE;2:PDG-RBE-BE-LBEX;3:;4:PDG-RBE-BE-LBEX;5:PDG-RBE-BE-LBEX;6:;7:PDG-RBE-BE-LBEX;
C1 Univ Montpellier, IFREMER, CNRS,UMR 5244, IHPE Interact Hosts Pathogens Environm,UPVD,CC 80, F-34095 Montpellier, France.
   IFREMER, Lab Ecotoxicol, Rue Ile Yeu,BP21105, F-44311 Nantes 03, France.
   Acobiom, 1682 Rue Valsiere, F-34184 Montpellier 04, France.
   Diag4Zoo, 1 Rue Loutres, F-34170 Montpellier, France.
C2 UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
   ACOBIOM, FRANCE
   DIAG4ZOO, FRANCE
SI MONTPELLIER
   NANTES
SE PDG-RBE-IHPE
   PDG-RBE-BE-LBEX
UM IHPE
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.974
TC 22
UR https://archimer.ifremer.fr/doc/00380/49106/89821.pdf
LA English
DT Article
DE ;Marine bivalve;Herbicide;Toxicogenomics;Survival;Biomarkers;Global DNA-methylation
AB One of the primary challenges in ecotoxicology is to contribute to the assessment of the ecological status of ecosystems. In this study, we used Pacific oyster Crassostrea gigas to explore the effects of a parental exposure to diuron, a herbicide frequently detected in marine coastal environments. The present toxicogenomic study provides evidence that exposure of oyster genitors to diuron during gametogenesis results in changes in offspring, namely, transcriptomic profile alterations, increased global DNA methylation levels and reduced growth and survival within the first year of life. Importantly, we highlighted the limitations to identify particular genes or gene expression signatures that could serve as biomarkers for parental herbicide-exposure and further for multigenerational and transgenerational effects of specific chemical stressors. By analyzing samples from two independent experiments, we demonstrated that, due to complex confounding effects with both tested solvent vehicles, diuron non-specifically affected the offspring transcriptome. These original results question the potential development of predictive genomic tools for detecting specific indirect impacts of contaminants in environmental risk assessments. However, our results indicate that chronic environmental exposure to diuron over several generations may have significant long term impacts on oyster populations with adverse health outcomes. 
PY 2017
PD AUG
SO Ecotoxicology And Environmental Safety
SN 0147-6513
PU Academic Press Inc Elsevier Science
VL 142
UT 000403384300007
BP 51
EP 58
DI 10.1016/j.ecoenv.2017.03.030
ID 49106
ER

EF