Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Type Article
Date 2017-05
Language English
Author(s) Adema Coen M.1, Hillier Ladeana W.2, Jones Catherine S.3, Loker Eric S.1, Knight Matty4, 5, 6, Minx Patrick2, Oliveira Guilherme7, 8, Raghavan Nithya9, Shedlock Andrew10, Do Amaral Laurence Rodrigues11, Arican-Goktas Halime D.12, Assis Juliana G.7, Baba Elio Hideo7, Baron Olga L.13, Bayne Christopher J.14, Bickham-Wright Utibe15, Biggar Kyle K.16, 17, Blouin Michael14, Bonning Bryony C.18, Botka Chris19, Bridger Joanna M.12, Buckley Katherine M.20, Buddenborg Sarah K.1, Caldeira Roberta Lima21, Carleton Julia22, Carvalho Omar S.21, Castillo Maria G.23, Chalmers Iain W.24, Christensens Mikkel25, Clifton Sandra2, Cosseau Celine26, Coustau Christine13, Cripps Richard M.27, Cuesta-Astroz Yesid7, Cummins Scott F.28, Di Stephano Leon29, 30, Dinguirard Nathalie15, Duval David26, Emrich Scott31, Feschotte Cedric22, Feyereisen Rene32, Fitzgerald Peter33, Fronick Catrina2, Fulton Lucinda2, Galinier Richard26, Gava Sandra G.7, Geusz Michael34, Geyer Kathrin K.24, Giraldo-Calderon Gloria I.31, Gomes Matheus De Souza11, Gordy Michelle A.35, Gourbal Benjamin26, Grunau Christoph26, Hanington Patrick C.35, Hoffmann Karl F.24, Hughes Daniel25, Humphries Judith36, Jackson Daniel J.37, Jannotti-Passos Liana K.7, Jeremias Wander De Jesus7, Jobling Susan38, Kamel Bishoy39, Kapusta Aurelie22, Kaur Satwant38, Koene Joris M.40, Kohn Andrea B.26, 41, Lawson Dan25, Lawton Scott P.42, Liang Di28, Limpanont Yanin28, Liu Sijun18, Lockyer Anne E.38, Lovato Tyanna L.27, Ludolf Fernanda7, Magrini Vince2, McManus Donald P.43, Medina Monica39, Misra Milind1, Mitta GuillaumeORCID26, Mkoji Gerald M.44, Montague Michael J.45, Montelongo Cesar23, Moroz Leonid L.41, Munoz-Torres Monica C.46, Niazi Umar24, Noble Leslie R.3, Oliveira Francislon S.7, Pais Fabiano S.7, Papenfuss Anthony T.29, 30, Peace Rob47, Pena Janeth J.1, Pila Emmanuel A.35, Quelais Titouan26, Raney Brian J.48, Rast Jonathan P.20, Rollinson David49, Rosse Izinara C.7, Rotgans Bronwyn28, Routledge Edwin J.38, Ryan Kathryn M.27, Scholte Larissa L. S.7, Storey Kenneth B.16, 17, Swain Martin24, Tennessen Jacob A.14, Tomlinson Chad2, Trujillo Damian L.27, Volpi Emanuela V.50, Walker Anthony J.42, Wang Tianfang28, Wannaporn Ittiprasert4, 5, Warren Wesley C.2, Wu Xiao-Jun15, Yoshino Timothy P.15, Yusuf Mohammed51, 52, Zhang Si-Ming1, Zhao Min28, Wilson Richard K.2
Affiliation(s) 1 : Univ New Mexico, Ctr Theoret & Evolutionary Immunol, Biol, Albuquerque, NM 87131 USA.
2 : Washington Univ, McDonnell Genome Inst, St Louis, MO 63108 USA.
3 : Univ Aberdeen, Sch Biol Sci, Inst Biol & Environm Sci, Tillydrone Ave, Aberdeen AB24 2TZ, Scotland.
4 : George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA.
5 : George Washington Univ, Sch Med & Hlth Sci, Res Ctr Neglected Dis Poverty, Washington, DC 20037 USA.
6 : Univ Dist Columbia, Div Sci & Math, 4200 Connecticut Ave NW, Washington, DC 20008 USA.
7 : FIOCRUZ Minas, Rene Rachou Res Ctr, BR-30190002 Belo Horizonte, MG, Brazil.
8 : Inst Tecnol Vale, BR-66055090 Belem, Para, Brazil.
9 : 10805 Tenbrook Dr, Silver Spring, MD 20901 USA.
10 : Med Univ South Carolina, Coll Charleston, Dept Biol, Coll Grad Studies,Hollings Marine Lab Charleston, Charleston, SC 29412 USA.
11 : Univ Fed Uberlandia, Lab Bioinformat & Mol Anal, Inst Genet & Biochem, Campus Patos de Minas UFU, BR-38700128 Patos De Minas, Brazil.
12 : Brunel Univ, Coll Hlth & Life Sci, Dept Life Sci, Uxbridge UB8 3PH, Middx, England.
13 : UNS, CNRS, INRA, Inst Sophia Agrobiotech, F-06903 Sophia Antipolis, France.
14 : Oregon State Univ, Dept Integrat Biol, 3029 Cordley Hall, Corvallis, OR 97331 USA.
15 : Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, 2015 Linden Dr, Madison, WI 53706 USA.
16 : Carleton Univ, Inst Biochem, Ottawa, ON K1S 5B6, Canada.
17 : Carleton Univ, Dept Biol, Ottawa, ON K1S 5B6, Canada.
18 : Iowa State Univ, Ames, IA 50011 USA.
19 : Harvard Med Sch, Dept Informat Technol, 107 Ave Louis Pasteur, Boston, MA 02115 USA.
20 : Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Immunol, 2075 Bayview Ave,Rm S126, Toronto, ON M4N 3M5, Canada.
21 : FIOCRUZ Minas, Lab Helmintol & Malacol Med, Rene Rachou Res Ctr, BR-30190002 Belo Horizonte, MG, Brazil.
22 : Univ Utah, Dept Human Genet, 15 North 2030 East, Salt Lake City, UT 84112 USA.
23 : New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA.
24 : Aberystwyth Univ, IBERS, Anim & Microbial Sci Res Theme, Aberystwyth SY23 3FG, Dyfed, Wales.
25 : EMBL EBI, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England.
26 : Univ Montpellier, IFREMER, Univ Perpignan, IHPE,UMR 5244,CNRS, Via Domitia, F-66860 Perpignan, France.
27 : Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA.
28 : Univ Sunshine Coast, Fac Sci Hlth & Educ, Maroochydore, Qld 4558, Australia.
29 : Walter & Eliza Hall Inst Med Res, 1G Royal Parade, Parkville, Vic 3052, Australia.
30 : Peter MacCallum Canc Ctr, Bioinformat & Canc Genom Lab Lorenzo & Pamela Gal, St Andrews Pl, East Melbourne, Vic 3002, Australia.
31 : Univ Notre Dame, Genom & Bioinformat Core Facil, 19 Galvin Life Sci, Notre Dame, IN 46556 USA.
32 : Univ Copenhagen, Fac Sci, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.
33 : NCI, Genome Anal Unit, NIH, Bethesda, MD 20892 USA.
34 : Bowling Green State Univ, Biol Sci, Bowling Green, OH 43403 USA.
35 : Univ Alberta, Dept Publ Hlth Sci, 3-57F South Acad Bldg, Edmonton, AB T6G 1C9, Canada.
36 : Lawrence Univ, Dept Biol, Appleton, WI 54911 USA.
37 : Georg August Univ Gottingen, Courant Res Ctr Geobiol, Goldschmidtstr 3, D-37077 Gottingen, Germany.
38 : Brunel Univ London, Inst Environm Hlth & Soc Environm & Hlth Theme, Uxbridge UB8 3PH, Middx, England.
39 : Penn State Univ, Dept Biol, University Pk, PA 16802 USA.
40 : Vrije Univ, Fac Aard & Levenswetenschappen, De Boelelaan 1085-1087, NL-1081 HV Amsterdam, Netherlands.
41 : Univ Florida, Whitney Lab Marine Biosci, 9505 Ocean Shore Blvd, St Augustine, FL 32080 USA.
42 : Kingston Univ, Sch Life Sci Pharm & Chem, Mol Parasitol Lab, Kingston Upon Thames KT1 2EE, Surrey, England.
43 : QIMR Berghofer Med Res Inst, Mol Parasitol Lab, Brisbane, Qld 4006, Australia.
44 : Kenya Govt Med Res Ctr, POB 54840, Nairobi 00200, Kenya.
45 : Univ Penn, Dept Neurosci, Perelman Sch Med, Philadelphia, PA 19104 USA.
46 : Lawrence Berkeley Natl Lab, Berkeley Bioinformat Open Source Projects, Environm Genom & Syst Biol Div, One Cyclotron Rd MS 977, Berkeley, CA 94720 USA.
47 : Carleton Univ, Dept Syst & Comp Engn, Ottawa, ON K1S 5B6, Canada.
48 : Univ Calif Santa Cruz, Genom Inst, Santa Cruz, CA 95064 USA.
49 : Nat Hist Museum, Dept Life Sci, Wolfson Wellcome Biomed Labs, Parasites & Vectors Div,London Ctr Neglected Trop, Cromwell Rd, London SW7 5BD, England.
50 : Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, 115 New Cavendish St, London W1W 6UW, England.
51 : UCL, London Ctr Nanotechnol, Gower St, London WC1E 6BT, England.
52 : Rutherford Appleton Lab, Res Complex Harwell, Didcot OX11 0FA, Oxon, England.
Source Nature Communications (2041-1723) (Nature Publishing Group), 2017-05 , Vol. 8 , N. 15451 , P. 12p.
DOI 10.1038/ncomms15451
WOS© Times Cited 149
Abstract Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
Full Text
File Pages Size Access
Publisher's official version 12 1 MB Open access
Supplementary Data 1 Sequence data sets 19 KB Open access
Supplementary Data 2 Biomphalaria glabrata linkage groups 666 KB Open access
Supplementary Data 3 Proteome InterProscan annotation 37 KB Open access
Supplementary Data 4 proteome KEGG/SNV mapping 37 KB Open access
Supplementary Data 5 Prediction of secreted proteins 25 KB Open access
Supplementary Data 6 fasta sequences of predicted secreted proteins (fasta) 267 KB Open access
Supplementary Data 7 secretome B. glabrata, Interproscan annotation 727 KB Open access
Supplementary Information Supplementary Figures, Supplementary Notes and Supplementary References 177 11 MB Open access
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Adema Coen M., Hillier Ladeana W., Jones Catherine S., Loker Eric S., Knight Matty, Minx Patrick, Oliveira Guilherme, Raghavan Nithya, Shedlock Andrew, Do Amaral Laurence Rodrigues, Arican-Goktas Halime D., Assis Juliana G., Baba Elio Hideo, Baron Olga L., Bayne Christopher J., Bickham-Wright Utibe, Biggar Kyle K., Blouin Michael, Bonning Bryony C., Botka Chris, Bridger Joanna M., Buckley Katherine M., Buddenborg Sarah K., Caldeira Roberta Lima, Carleton Julia, Carvalho Omar S., Castillo Maria G., Chalmers Iain W., Christensens Mikkel, Clifton Sandra, Cosseau Celine, Coustau Christine, Cripps Richard M., Cuesta-Astroz Yesid, Cummins Scott F., Di Stephano Leon, Dinguirard Nathalie, Duval David, Emrich Scott, Feschotte Cedric, Feyereisen Rene, Fitzgerald Peter, Fronick Catrina, Fulton Lucinda, Galinier Richard, Gava Sandra G., Geusz Michael, Geyer Kathrin K., Giraldo-Calderon Gloria I., Gomes Matheus De Souza, Gordy Michelle A., Gourbal Benjamin, Grunau Christoph, Hanington Patrick C., Hoffmann Karl F., Hughes Daniel, Humphries Judith, Jackson Daniel J., Jannotti-Passos Liana K., Jeremias Wander De Jesus, Jobling Susan, Kamel Bishoy, Kapusta Aurelie, Kaur Satwant, Koene Joris M., Kohn Andrea B., Lawson Dan, Lawton Scott P., Liang Di, Limpanont Yanin, Liu Sijun, Lockyer Anne E., Lovato Tyanna L., Ludolf Fernanda, Magrini Vince, McManus Donald P., Medina Monica, Misra Milind, Mitta Guillaume, Mkoji Gerald M., Montague Michael J., Montelongo Cesar, Moroz Leonid L., Munoz-Torres Monica C., Niazi Umar, Noble Leslie R., Oliveira Francislon S., Pais Fabiano S., Papenfuss Anthony T., Peace Rob, Pena Janeth J., Pila Emmanuel A., Quelais Titouan, Raney Brian J., Rast Jonathan P., Rollinson David, Rosse Izinara C., Rotgans Bronwyn, Routledge Edwin J., Ryan Kathryn M., Scholte Larissa L. S., Storey Kenneth B., Swain Martin, Tennessen Jacob A., Tomlinson Chad, Trujillo Damian L., Volpi Emanuela V., Walker Anthony J., Wang Tianfang, Wannaporn Ittiprasert, Warren Wesley C., Wu Xiao-Jun, Yoshino Timothy P., Yusuf Mohammed, Zhang Si-Ming, Zhao Min, Wilson Richard K. (2017). Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, 8(15451), 12p. Publisher's official version : https://doi.org/10.1038/ncomms15451 , Open Access version : https://archimer.ifremer.fr/doc/00387/49840/