FN Archimer Export Format
PT J
TI A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni
BT 
AF GALINIER, Richard
   ROGER, Emmanuel
   MONE, Yves
   DUVAL, David
   PORTET, Anais
   PINAUD, Silvain
   CHAPARRO, Cristian
   GRUNAU, Christoph
   GENTHON, Clemence
   DUBOIS, Emeric
   ROGNON, Anne
   ARANCIBIA, Nathalie
   DEJEAN, Bernard
   THERON, Andre
   GOURBAL, Benjamin
   MITTA, Guillaume
AS 1:1;2:1;3:1;4:1;5:1;6:1;7:1;8:1;9:2;10:2;11:1;12:1;13:1;14:1;15:1;16:;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;16:;
C1 Univ Montpellier, Univ Perpignan, CNRS, IFREMER,IHPE UMR 5244, Via Domitia, Perpignan, France.
   Montpellier Genom & Bioinformat Facil, MGX Montpellier GenomiX, Montpellier, France.
C2 UNIV MONTPELLIER, FRANCE
   UNIV MONTPELLIER, FRANCE
UM IHPE
IN DOAJ
IF 4.367
TC 31
UR https://archimer.ifremer.fr/doc/00388/49951/50515.pdf
   https://archimer.ifremer.fr/doc/00388/49951/50516.pdf
   https://archimer.ifremer.fr/doc/00388/49951/50517.xls
   https://archimer.ifremer.fr/doc/00388/49951/50518.xlsx
   https://archimer.ifremer.fr/doc/00388/49951/50519.xlsx
   https://archimer.ifremer.fr/doc/00388/49951/50520.xlsx
LA English
DT Article
AB In recent decades, numerous studies have sought to better understand the mechanisms underlying the compatibility between Biomphalaria glabrata and Schistosoma mansoni. The developments of comparative transcriptomics, comparative genomics, interactomics and more targeted approaches have enabled researchers to identify a series of candidate genes. However, no molecular comparative work has yet been performed on multiple populations displaying different levels of compatibility. Here, we seek to fill this gap in the literature. We focused on B. glabrata FREPs and S. mansoni SmPoMucs, which were previously demonstrated to be involved in snail/schistosome compatibility. We studied the expression and polymorphisms of these factors in combinations of snail and schistosome isolates that display different levels of compatibility. We found that the polymorphism and expression levels of FREPs and SmPoMucs could be linked to the compatibility level of S. mansoni. These data and our complementary results obtained by RNA-seq of samples from various snail strains indicate that the mechanism of compatibility is much more complex than previously thought, and that it is likely to be highly variable within and between populations. This complexity must be taken into account if we hope to identify the molecular pathways that are most likely to be good targets for strategies aimed at blocking transmission of the parasite through the snail intermediate host. 
PY 2017
PD MAR
SO Plos Neglected Tropical Diseases
SN 1935-2735
PU Public Library Science
VL 11
IS 3
UT 000402251300019
DI 10.1371/journal.pntd.0005398
ID 49951
ER

EF