FN Archimer Export Format PT J TI Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms BT AF DI POI, Carole COSTIL, Katherine BOUCHART, Valerie HALM-LEMEILLE, Marie-Pierre AS 1:1,2;2:1;3:3;4:4,5; FF 1:PDG-RBE-PFOM-LPI;2:;3:;4:PDG-ODE-LITTORAL-LERN; C1 Univ Caen Normandie, CNRS, UPMC, UCBN,BOREA,MNHN,UMR 7208,IRD 207,CS 14032, F-14032 Caen, France. CNRS, Ctr Bretagne, IFREMER, LEMAR,UMR 6539,UBO,IRD,ZI Pointe Diable,CS 10070, F-29280 Plouzane, France. Lab LABEO Frank Duncombe, 1 Route Rosel, F-14053 Caen 4, France. Univ Caen Normandie, CNRS, ICORE, CERMN,UNICAEN,EA 4258,FR 3038,INC3M,SF 4206, Blvd Becquerel, F-14032 Caen, France. IFREMER, LER, Stn Port Bessin, Ave Gen Gaulle,BP 32, F-14520 Port En Bessin, France. C2 MNHN, FRANCE IFREMER, FRANCE LABEO FRANK DUNCOMBE, FRANCE UNIV CAEN NORMANDIE, FRANCE IFREMER, FRANCE SI ARGENTON PORT-EN-BESSIN SE PDG-RBE-PFOM-LPI PDG-ODE-LITTORAL-LERN UM LEMAR IN WOS Ifremer jusqu'en 2018 copubli-france copubli-univ-france IF 2.914 TC 69 UR https://archimer.ifremer.fr/doc/00389/50004/52260.pdf LA English DT Article DE ;Pharmaceuticals;Personal care products;Pesticides;Mixture and single-compound toxicity;Freshwater species;Marine bivalve AB Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ). The acute or sub-chronic toxicity, alone or in binary/ternary mixtures of three of them (CBZ, AMPA, and MP), was assessed on one marine and two freshwater organisms: Crassostrea gigas, Pseudokirchneriella subcapitata, and Daphnia magna. TCS and AMPA were, respectively, the most (EC50 < 1 mg L−1) and the least (EC50 > 50 mg L−1) toxic chemicals for the four endpoints (algal growth inhibition, daphnia immobilization, oyster embryotoxicity, and metamorphosis). The anxiolytic VEN (EC50 < 1 mg L−1) was particularly toxic to oyster larvae showing sensitivity difference between freshwater and marine organisms. If all the mixtures appeared to be in the same range of toxicity, the joint-toxic effects mainly led to synergistic or antagonistic interactions compared to single-compound toxicity. The data also highlighted species-dependent differing models of toxicity and underscored the need for an awareness of cocktail effects for better ecological risk assessment. PY 2018 PD MAR SO Environmental Science And Pollution Research SN 0944-1344 PU Springer Heidelberg VL 25 IS 7 UT 000426571000005 BP 6122 EP 6134 DI 10.1007/s11356-017-9306-9 ID 50004 ER EF