FN Archimer Export Format
PT J
TI Regulation of the corticosteroid signalling system in rainbow trout HPI axis during confinement stress.
BT 
AF KIILERICH, Pia
   SERVILI, Arianna
   PERON, Sandrine
   VALOTAIRE, Claudiane
   GOARDON, Lionel
   LEGUEN, Isabelle
   PRUNET, Patrick
AS 1:1,4;2:2;3:1;4:1;5:3;6:1;7:1;
FF 1:;2:PDG-RBE-PFOM-LARN;3:;4:;5:;6:;7:;
C1 INRA, UR1037, Fish Physiol & Genom, Campus Beaulieu, F-35042 Rennes, France.
   IFREMER, Unite Physiol Fonct Organismes Marins, LEMAR, UMR 6539, BP 70, F-29280 Plouzane, France.
   INRA, Pisciculture Expt Mt Arree UE937, F-29450 Sizun, France.
   Univ Copenhagen, Dept Biol, Copenhagen, Denmark.
C2 INRA, FRANCE
   IFREMER, FRANCE
   INRA, FRANCE
   UNIV COPENHAGEN, DENMARK
SI BREST
SE PDG-RBE-PFOM-LARN
UM LEMAR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-p187
   copubli-europe
IF 2.445
TC 33
UR https://archimer.ifremer.fr/doc/00396/50737/51439.pdf
LA English
DT Article
DE ;Stress;Rainbow trout;Confinement;Cortisol;DOC;MR;GR1;GR2;HPI-axis
AB This study aims to shed light on corticosteroid regulation of stress in teleost fish with focus on the corticosteroid signalling system. The role of the mineralocorticoid-like hormone 11-deoxycorticosterone (DOC) in fish is still enigmatic, as is the function of the mineralocorticoid receptor, MR. Low plasma DOC levels and ubiquitous tissue distribution of MR question the physiological relevance of the mineralocorticoid-axis. Furthermore, the particular purpose of each of the three corticosteroid receptors in fish, the glucocorticoid receptors, GR1 and GR2, and the MR, is still largely unknown. Therefore we investigate the regulation of cortisol and DOC in plasma and mRNA levels of MR, GR1 and GR2 in the HPI-axis tissue (hypothalamus, pituitary and interrenal gland) during a detailed confinement stress time-course. Here we show a sustained up-regulation of plasma DOC levels during a confinement stress time-course. However, the low DOC levels compared to cortisol measured in the plasma do not favour an activity of DOC through MR receptors. Furthermore, we show differential contribution of the CRs in regulation and control of HPI axis activity following confinement stress. Judged by the variation of mRNA levels negative feedback regulation of cortisol release occurs on the level of the pituitary via MR and on the level of the interrenal gland via GR2. Finally, as a significant effect of confinement stress on CR expressions was observed in the pituitary gland, we completed this experiment by demonstrating that corticosteroid receptors (GR1, GR2 and MR) are co-expressed in the ACTH cells located in the adenohypophysis. Overall, these data suggest the involvement of these receptors in the regulation of the HPI axis activity by cortisol. 
PY 2018
PD MAR
SO General And Comparative Endocrinology
SN 0016-6480
PU Academic Press Inc Elsevier Science
VL 258
UT 000426026200020
BP 184
EP 193
DI 10.1016/j.ygcen.2017.08.013
ID 50737
ER

EF