FN Archimer Export Format
PT J
TI Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas
BT 
AF LAFONT, Maxime
   PETTON, Bruno
   VERGNES, Agnes
   PAULETTO, Marianna
   SEGARRA, Amelie
   GOURBAL, Benjamin
   MONTAGNANI, Caroline
AS 1:1,2;2:3;3:1;4:4;5:5;6:2;7:1;
FF 1:;2:PDG-RBE-PFOM-PI;3:PDG-RBE-IHPE;4:;5:;6:;7:;
C1 Univ Montpellier, Univ Perpignan, CNRS, Ifremer,IHPE,UMR 5244, Via Domitia, F-34095 Montpellier, France.
   Univ Montpellier, Univ Perpignan, CNRS, IFREMER,IHPE UMR 5244, Via Domitia, F-66860 Perpignan, France.
   IFREMER, LEMAR UMR6539, F-29840 Argenton En Landunvez, France.
   Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, I-35020 Legnaro, PD, Italy.
   Univ Brest Occidentale, LEMAR UMR CNRS UBO IRD Ifremer 6539, Inst Univ Europeen Mer, F-29280 Plouzane, France.
C2 IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
   UNIV PADUA, ITALY
   UBO, FRANCE
SI ARGENTON
   MONTPELLIER
SE PDG-RBE-PFOM-PI
   PDG-RBE-IHPE
UM LEMAR
   IHPE
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
IF 4.122
TC 48
UR https://archimer.ifremer.fr/doc/00407/51811/52413.pdf
   https://archimer.ifremer.fr/doc/00407/51811/52414.pdf
LA English
DT Article
AB In the last decade, a paradigm shift has emerged in comparative immunology. Invertebrates can no longer be considered to be devoid of specific recognition and immune memory. However, we still lack a comprehensive view of these phenomena and their molecular mechanisms across phyla, especially in terms of duration, specificity, and efficiency in a natural context. In this study, we focused on a Lophotrochozoan/virus interaction, as antiviral priming is mostly overlooked in molluscs. Juvenile Crassostrea gigas oysters experience reoccurring mass mortalities events from Ostreid herpes virus 1 with no existing therapeutic treatment. Our results showed that various nucleic acid injections can prime oysters to trigger an antiviral state ultimately protecting them against a subsequent viral infection. Focusing on poly(I:C) as elicitor, we evidenced that it protected from an environmental infection, by mitigating viral replication. That protection seemed to induce a specific antiviral response as poly(I:C) fails to protect against a pathogenic bacteria. Finally, we showed that this phenomenon was long-lasting, persisting for at least 5 months thus suggesting for the first time the existence of innate immune memory in this invertebrate species. This study strengthens the emerging hypotheses about the broad conservation of innate immune priming and memory mechanisms in Lophotrochozoans. 
PY 2017
PD OCT
SO Scientific Reports
SN 2045-2322
PU Nature Publishing Group
VL 7
IS 13143
UT 000412956900033
BP 1
EP 14
DI 10.1038/s41598-017-13564-0
ID 51811
ER

EF