FN Archimer Export Format
PT J
TI Variation in Metabolic Rate among Individuals Is Related to Tissue-Specific Differences in Mitochondrial Leak Respiration
BT 
AF SALIN, Karine
   AUER, Sonya K.
   RUDOLF, Agata M.
   ANDERSON, Graeme J.
   SELMAN, Colin
   METCALFE, Neil B.
AS 1:1;2:1;3:2;4:1;5:1;6:1;
FF 1:;2:;3:;4:;5:;6:;
C1 Univ Glasgow, Coll Med Vet & Life Sci, Inst Biodivers Anim Hlth & Comparat Med, Glasgow G12 8QQ, Lanark, Scotland.
   Jagiellonian Univ, Inst Environm Sci, Gronostajowa 7, PL-30387 Krakow, Poland.
C2 UNIV GLASGOW, UK
   UNIV JAGIELLONIAN, POLAND
IF 2.104
TC 45
UR https://archimer.ifremer.fr/doc/00413/52497/53321.pdf
LA English
DT Article
DE ;brown trout;fish;liver;oxygen consumption;white muscle
AB Standard metabolic rate (SMR) and maximum metabolic rate (MMR) typically vary two-or threefold among conspecifics, with both traits assumed to significantly impact fitness. However, the underlying mechanisms that determine such intraspecific variation are not well understood. We examined the influence of mitochondrial properties on intraspecific variation in SMR and MMR and hypothesized that if SMR supports the cost of maintaining the metabolic machinery required for MMR, then the mitochondrial properties underlying these traits should be shared. Mitochondrial respiratory capacity (leak and phosphorylating respiration) and mitochondrial content (cytochrome c oxidase activity) were determined in the liver and white muscle of brown trout Salmo trutta of similar age and maintenance conditions. SMR and MMR were uncorrelated across individuals and were not associated with the same mitochondrial properties, suggesting that they are under the control of separate physiological processes. Moreover, tissue-specific relationships between mitochondrial properties and whole-organism metabolic traits were observed. Specifically, SMR was positively associated with leak respiration in liver mitochondria, while MMR was positively associated with muscle mitochondrial leak respiration and mitochondrial content. These results suggest that a high SMR or MMR, rather than signaling a higher ability for respiration-driven ATP synthesis, may actually reflect greater dissipation of energy, driven by proton leak across the mitochondrial inner membrane. Knowledge of these links should aid interpretation of the potential fitness consequences of such variation in metabolism, given the importance of mitochondria in the utilization of resources and their allocation to performance.
PY 2016
PD NOV
SO Physiological And Biochemical Zoology
SN 1522-2152
PU Univ Chicago Press
VL 89
IS 6
UT 000387262000006
BP 511
EP 523
DI 10.1086/688769
ID 52497
ER

EF