FN Archimer Export Format
PT J
TI Antagonistic evolution of an antibiotic and its molecular chaperone: how to maintain a vital ectosymbiosis in a highly fluctuating habitat
BT 
AF PAPOT, Claire
   MASSOL, Francois
   JOLLIVET, Didier
   TASIEMSKI, Aurelie
AS 1:1;2:1;3:2;4:1;
FF 1:;2:;3:;4:;
C1 Univ Lille, CNRS, UMR Evoecopaleo 8198, SPICI Grp, F-59000 Lille, France.
   Univ Paris 06, CNRS, AD2M, ABICE Team,UMR7144,Stn Biol Roscoff, F-29682 Roscoff, France.
C2 UNIV LILLE, FRANCE
   UNIV PARIS 06, FRANCE
IF 4.122
TC 8
UR https://archimer.ifremer.fr/doc/00414/52539/53350.pdf
   https://archimer.ifremer.fr/doc/00414/52539/53351.pdf
   https://archimer.ifremer.fr/doc/00414/52539/53352.pdf
LA English
DT Article
CR BIOSPEEDO
   MESCAL
BO L'Atalante
AB Evolution of antimicrobial peptides (AMPs) has been shown to be driven by recurrent duplications and balancing/positive selection in response to new or altered bacterial pathogens. We use Alvinella pompejana, the most eurythermal animal known on Earth, to decipher the selection patterns acting on AMP in an ecological rather than controlled infection approach. The preproalvinellacin multigenic family presents the uniqueness to encode a molecular chaperone (BRICHOS) together with an AMP (alvinellacin) that controls the vital ectosymbiosis of Alvinella. In stark contrast to what is observed in the context of the Red queen paradigm, we demonstrate that exhibiting a vital and highly conserved ecto-symbiosis in the face of thermal fluctuations has led to a peculiar selective trend promoting the adaptive diversification of the molecular chaperone of the AMP, but not of the AMP itself. Because BRICHOS stabilizes beta-stranded peptides, this polymorphism likely represents an eurythermal adaptation to stabilize the structure of alvinellacin, thus hinting at its efficiency to select and control the epibiosis across the range of temperatures experienced by the worm; Our results fill some knowledge gaps concerning the function of BRICHOS in invertebrates and offer perspectives for studying immune genes in an evolutionary ecological framework. 
PY 2017
PD MAY
SO Scientific Reports
SN 2045-2322
PU Nature Publishing Group
VL 7
IS 1
UT 000400491900010
DI 10.1038/s41598-017-01626-2
ID 52539
ER

EF