FN Archimer Export Format
PT J
TI A biomolecular proportional integral controller based on feedback regulations of protein level and activity
BT 
AF MAIRET, Francis
AS 1:1,2;
FF 1:PDG-RBE-BRM-LPBA;
C1 INRIA, Biocore, Sophia Antipolis, France.
   IFREMER, Physiol & Biotechnol Algae Lab, Nantes, France.
C2 INRIA, FRANCE
   IFREMER, FRANCE
SI NANTES
SE PDG-RBE-BRM-LPBA
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
IF 2.515
TC 12
UR https://archimer.ifremer.fr/doc/00434/54598/55968.pdf
LA English
DT Article
DE ;homeostasis;perfect adaptation;regulatory motif;transcriptional and post-translational regulations
AB Homeostasis is the capacity of living organisms to keep internal conditions regulated at a constant level, despite environmental fluctuations. Integral feedback control is known to play a key role in this behaviour. Here, I show that a feedback system involving transcriptional and post-translational regulations of the same executor protein acts as a proportional integral (PI) controller, leading to enhanced transient performances in comparison with a classical integral loop. Such a biomolecular controller-which I call a level and activity-PI controller (LA-PI)-is involved in the regulation of ammonium uptake by Escherichia coli through the transporter AmtB. The P-II molecules, which reflect the nitrogen status of the cell, inhibit both the production of AmtB and its activity (via the NtrB-NtrC system and the formation of a complex with GlnK, respectively). Other examples of LA-PI controller include copper and zinc transporters, and the redox regulation in photosynthesis. This scheme has thus emerged through evolution in many biological systems, surely because of the benefits it offers in terms of performances (rapid and perfect adaptation) and economy (protein production according to needs). 
PY 2018
PD FEB
SO Royal Society Open Science
SN 2054-5703
PU Royal Soc
VL 5
IS 2
UT 000426465700079
DI 10.1098/rsos.171966
ID 54598
ER

EF