FN Archimer Export Format
PT J
TI Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
BT 
AF EL-DEMERDASH, Amr
   MORIOU, Celine
   TOULLEC, Jordan
   BESSON, Marc
   SOULET, Stephanie
   SCHMITT, Nelly
   PETEK, Sylvain
   LECCHINI, David
   DEBITUS, Cecile
   AL-MOURABIT, Ali
AS 1:1,2;2:1;3:3;4:4,5;5:6;6:6;7:3;8:4;9:3;10:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;
C1 Univ Paris Saclay, Univ Paris Sud, CNRS, UPR 2301,Inst Chim Subst Nat, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France.
   Mansoura Univ, Div Organ Chem, Dept Chem, Fac Sci, Mansoura 35516, Egypt.
   UBO, IFREMER, IUEM, LEMAR,IRD,CNRS, F-29280 Plouzane, France.
   PSL Res Univ, CNRS, CRIOBE, EPHE,UPVD, F-98729 Moorea, French Polynesi, France.
   Univ Pierre & Marie Curie Paris, Observ Oceanol Banyuls Sur Mer, F-66650 Banyuls Sur Mer, France.
   UPF, EIO, ILM, IFREMER,IRD, F-98702 Tahiti, French Polynesi, France.
C2 UNIV PARIS SACLAY, FRANCE
   UNIV MANSOURA, EGYPT
   UBO, FRANCE
   CRIOBE, FRANCE
   UNIV PARIS 06, FRANCE
   IRD, FRANCE
UM LEMAR
IN DOAJ
IF 3.772
TC 15
UR https://archimer.ifremer.fr/doc/00439/55076/56506.pdf
   https://archimer.ifremer.fr/doc/00439/55076/56507.pdf
LA English
DT Article
DE ;brominated tyrosine alkaloids;Suberea ianthelliformis;cytotoxicity;acetylcholinesterase inhibition
AB Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively. 
PY 2018
PD MAY
SO Marine Drugs
SN 1660-3397
PU Mdpi
VL 16
IS 5
UT 000435195100009
DI 10.3390/md16050146
ID 55076
ER

EF