FN Archimer Export Format
PT J
TI Metabolomic Profiles of Dinophysis acuminata and Dinophysis acuta Using Non-Targeted High-Resolution Mass Spectrometry: Effect of Nutritional Status and Prey
BT 
AF GARCIA-PORTELA, Maria
   REGUERA, Beatriz
   SIBAT, Manoella
   ALTENBURGER, Andreas
   RODRIGUEZ, Francisco
   HESS, Philipp
AS 1:1;2:1;3:2;4:3;5:1;6:2;
FF 1:;2:;3:PDG-ODE-DYNECO-PHYC;4:;5:;6:PDG-ODE-DYNECO-PHYC;
C1 IEO, Oceanog Ctr Vigo, Subida Radio Faro 50, Vigo 36390, Spain.
   IFREMER, Phycotoxins Lab, Rue Ile Yeu,BP 21105, F-44311 Nantes, France.
   Univ Copenhagen, Nat Hist Museum Denmark, Oster Voldgade 5-7, DK-1350 Copenhagen, Denmark.
C2 IEO, SPAIN
   IFREMER, FRANCE
   UNIV COPENHAGEN, DENMARK
SI NANTES
SE PDG-ODE-DYNECO-PHYC
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-europe
IF 3.772
TC 12
UR https://archimer.ifremer.fr/doc/00439/55077/56508.pdf
   https://archimer.ifremer.fr/doc/00439/55077/56509.xlsx
LA English
DT Article
DE ;Dinophysis physiology;lipophilic toxins;non-targeted analysis;metabolomics
AB Photosynthetic species of the genus Dinophysis are obligate mixotrophs with temporary plastids (kleptoplastids) that are acquired from the ciliate Mesodinium rubrum, which feeds on cryptophytes of the Teleaulax-Plagioselmis-Geminigera clade. A metabolomic study of the three-species food chain Dinophysis-Mesodinium-Teleaulax was carried out using mass spectrometric analysis of extracts of batch-cultured cells of each level of that food chain. The main goal was to compare the metabolomic expression of Galician strains of Dinophysis acuminata and D. acuta that were subjected to different feeding regimes (well-fed and prey-limited) and feeding on two Mesodinium (Spanish and Danish) strains. Both Dinophysis species were able to grow while feeding on both Mesodinium strains, although differences in growth rates were observed. Toxin and metabolomic profiles of the two Dinophysis species were significantly different, and also varied between different feeding regimes and different prey organisms. Furthermore, significantly different metabolomes were expressed by a strain of D. acuminata that was feeding on different strains of the ciliate Mesodinium rubrum. Both species-specific metabolites and those common to D. acuminata and D. acuta were tentatively identified by screening of METLIN and Marine Natural Products Dictionary databases. This first metabolomic study applied to Dinophysis acuminata and D.acuta in culture establishes a basis for the chemical inventory of these species 
PY 2018
PD MAY
SO Marine Drugs
SN 1660-3397
PU Mdpi
VL 16
IS 5
UT 000435195100006
DI 10.3390/md16050143
ID 55077
ER

EF