FN Archimer Export Format PT J TI Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme BT AF DELZOR, Aurelie COURATIER, Philippe BOUMEDIENE, Farid NICOL, Marie DRUET-CABANAC, Michel PARAF, Francois MEJEAN, Annick PLOUX, Olivier LELEU, Jean-Philippe BRIENT, Luc LENGRONNE, Marion PICHON, Valerie COMBES, Audrey EL ABDELLAOUI, Saida BONNETERRE, Vincent LAGRANGE, Emmeline BESSON, Gerard BICOUT, Dominique J. BOUTONNAT, Jean CAMU, William PAGEOT, Nicolas JUNTAS-MORALES, Raul RIGAU, Valerie MASSERET, Estelle ABADIE, Eric PREUX, Pierre-Marie MARIN, Benoit AS 1:1,2;2:1,2,3;3:1,2;4:1,2,3;5:1,2,3;6:3;7:4;8:4;9:1,2;10:5;11:5;12:6,7;13:6,7;14:6,7;15:8;16:9;17:9;18:8,10;19:9;20:11,12;21:11,12;22:11,12;23:11,12;24:13;25:14;26:1,2,3;27:1,2; FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;16:;17:;18:;19:;20:;21:;22:;23:;24:;25:PDG-ODE-LITTORAL-LERLR;26:;27:; C1 INSERM, UMR 1094, Trop Neuroepidemiol, Limoges, France. Univ Limoges, Sch Med, Inst Neuroepidemiol & Trop Neurol, CNRS,FR GIEST 3503, Limoges, France. Univ Hosp Dupuytren, Dept Neurol, ALS Ctr, Limoges, France. Univ Paris Diderot Paris 7, CNRS UMR 8236, Interdisciplinary Lab Tomorrows Energy Pack LIED, Paris, France. Univ Rennes 1, Ecosyst Biodivers Evolut, ECOBIO, UMR 6553, Rennes, France. ParisTech, CNRS CBI 8231, Dept Analyt Bioanalyt Sci & Miniaturizat LSABM, UMR ESPCI, Paris, France. UPMC, Univ Sorbonne, Paris, France. UJF Grenoble 1, UMR 5525, CNRS TIMC IMAG, Environm & Hlth Predict Populat EPSP, Grenoble, France. Univ Hosp Grenoble, Dept Neurol, Grenoble, France. VetAgro Sup, Environm & Hlth Predict Populat EPSP, Biomath & Epidemiol, Marcy Letoile, France. INSERM, Neurosci Inst, UMR 1051, Motoneuron Dis Neuroinflammat & Therapy, Montpellier, France. Univ Hosp Gui Chauliac, ALS Ctr, Dept Neurol, Montpellier, France. Univ Montpellier II, CNRS IRD Ifremer UM1 UM2, Ecol Coastal Marine Syst, ECOSYM,UMR 5119, Montpellier, France. Ifremer, Environm Resources Lab Languedoc Roussillon, Sete, France. C2 INSERM, FRANCE UNIV LIMOGES, FRANCE HOSP UNIV DUPUYTREN, FRANCE UNIV PARIS 07, FRANCE UNIV RENNES, FRANCE PARISTECH, FRANCE UNIV PARIS 06, FRANCE UNIV GRENOBLE, FRANCE UNIV HOSP GRENOBLE, FRANCE VETAGRO SUP, FRANCE INSERM, FRANCE UNIV HOSP GUI CHAULIAC, FRANCE UNIV MONTPELLIER II, FRANCE IFREMER, FRANCE SI SETE SE PDG-ODE-LITTORAL-LERLR IN WOS Ifremer jusqu'en 2018 copubli-france copubli-univ-france IF 2.271 TC 17 UR https://archimer.ifremer.fr/doc/00443/55431/56952.pdf LA English DT Article AB Introduction: Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disease. It occurs in two forms: (1) familial cases, for which several genes have been identified and (2) sporadic cases, for which various hypotheses have been formulated. Notably, the beta-N-methylamino-L-alanine (L-BMAA) toxin has been postulated to be involved in the occurrence of sporadic ALS. The objective of the French BMAALS programme is to study the putative link between L-BMAA and ALS. Methods and analysis: The programme covers the period from 1 January 2003 to 31 December 2011. Using multiple sources of ascertainment, all the incident ALS cases diagnosed during this period in the area under study (10 counties spread over three French regions) were collected. First, the standardised incidence ratio will be calculated for each municipality under concern. Then, by applying spatial clustering techniques, overincidence and underincidence zones of ALS will be sought. A casecontrol study, in the subpopulation living in the identified areas, will gather information about patients' occupations, leisure activities and lifestyle habits in order to assess potential risk factors to which they are or have been exposed. Specimens of drinking water, food and biological material (brain tissue) will be examined to assess the presence of LBMAA in the environment and tissues of ALS cases and controls. Ethics and dissemination: The study has been reviewed and approved by the French ethical committee of the CPP SOOM IV (Comite de Protection des Personnes Sud-Ouest & Outre-Mer IV). The results will be published in peer-reviewed journals and presented at national and international conferences. PY 2014 PD AUG SO Bmj Open SN 2044-6055 PU Bmj Publishing Group VL 4 IS 8 UT 000412123900001 DI 10.1136/bmjopen-2014-005528 ID 55431 ER EF