FN Archimer Export Format
PT J
TI Enhanced brain expression of genes related to cell proliferation and neural differentiation is associated with cortisol receptor expression in fishes
BT 
AF SADOUL, Bastien
   ALFONSO, Sebastien
   BESSA, E.
   BOUCHAREB, A.
   BLONDEAU-BIDET, E.
   CLAIR, P.
   CHATAIN, Beatrice
   BEGOUT, Marie-Laure
   GEFFROY, Benjamin
AS 1:1;2:1,2;3:3;4:4;5:6;6:5;7:1;8:2;9:1;
FF 1:;2:PDG-RBE-MARBEC-LAAAS;3:;4:;5:;6:;7:PDG-RBE-MARBEC-LAAAS;8:PDG-RBE-HGS;9:PDG-RBE-MARBEC-LAAAS;
C1 Univ Montpellier, MARBEC, Ifremer, CNRS,IRD, Palavas Les Flots, France.
   Ifremer, Lab Ressources Halieut La Rochelle, Pl Gaby Coll, Lhoumeau, France.
   Univ Brasilia, Grad Program Ecol, Brasilia, DF, Brazil.
   Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
   Univ Montpellier, Montpellier GenomiX, Montpellier, France.
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV BRASILIA, BRAZIL
   UNIV OXFORD, UK
   UNIV MONTPELLIER, FRANCE
   CNRS, FRANCE
SI PALAVAS
   LA ROCHELLE
SE PDG-RBE-MARBEC-LAAAS
   PDG-RBE-HGS
UM MARBEC
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
   copubli-sud
IF 2.445
TC 21
UR https://archimer.ifremer.fr/doc/00444/55560/57164.pdf
LA English
DT Article
DE ;Neurogenesis;Stress;Glucocorticoid receptor;Mineralocorticoid receptor;Hypothalamo-pituitary-interrenal axis
AB Stress enhances or inhibits neurogenesis in mammals and some fish species. The link between the two processes is still unclear. Most studies have been performed in very specific stressful or altered environments. Despite the known inter-individual divergence in coping abilities within populations, the relationship between the stress axis and neurogenesis has never been addressed in unstressed individuals. Here we correlate brain expression of the pcna (proliferating cell nuclear antigen) and neurod1 (neurogenic differentiation factor 1) genes, two markers of neurogenesis, with transcripts of cortisol receptors in three fish species living in very distinct environments. Within the three species, individuals with the highest expression of neurogenesis genes were also those that expressed the high levels of cortisol receptors. Based on these correlations and the hypothesis that mRNA levels are proxies of protein levels, we hypothesize that within unstressed animals, individuals sensitive to cortisol perceive a similar environment to be more stimulating, leading to increased neurogenesis. Although it is difficult to determine whether it is sensitivity to cortisol that affects neurogenesis capacities or the opposite, the proposed pathway is a potentially fruitful avenue that warrants further mechanistic experiments. 
PY 2018
PD OCT
SO General And Comparative Endocrinology
SN 0016-6480
PU Academic Press Inc Elsevier Science
VL 267
UT 000444366400010
BP 76
EP 81
DI 10.1016/j.ygcen.2018.06.001
ID 55560
ER

EF