FN Archimer Export Format PT J TI Determination of risk factors for herpesvirus outbreak in oysters using a broad-scale spatial epidemiology framework BT AF PERNET, Fabrice FUHRMANN, Marine PETTON, Bruno MAZURIE, Joseph BOUGET, Jean-Francois FLEURY, Elodie DAIGLE, Gaetan GERNEZ, Pierre AS 1:1;2:1;3:2;4:3;5:3;6:1;7:4;8:5; FF 1:PDG-RBE-PFOM-LPI;2:;3:PDG-RBE-PFOM-LPI;4:PDG-ODE-LITTORAL-LERMPL;5:PDG-ODE-LITTORAL-LERMPL;6:PDG-RBE-PFOM-LPI;7:;8:; C1 Ifremer, LEMAR UMR 6539, Unite Physiol Fonct Organisme Marins, Technopole Brest Iroise, Plouzane, France. Ifremer, LEMAR UMR 6539, Unite Physiol Fonct Organisme Marins, Argenton, France. Ifremer, Lab Environm Ressource Morbihan Pays Loire, Unite Littorale, 12 Rue Resistants, La Trinite Sur Mer, France. Univ Laval, Dept Math & Stat, Pavillon Alexandre Vachon, Quebec City, PQ, Canada. Univ Nantes, Mer Mol Sante EA 2160, Nantes, France. C2 IFREMER, FRANCE IFREMER, FRANCE IFREMER, FRANCE UNIV LAVAL, CANADA UNIV NANTES, FRANCE SI BREST ARGENTON LA TRINITE SE PDG-RBE-PFOM-LPI PDG-ODE-LITTORAL-LERMPL UM LEMAR IN WOS Ifremer jusqu'en 2018 DOAJ copubli-france copubli-univ-france copubli-int-hors-europe IF 4.011 TC 27 UR https://archimer.ifremer.fr/doc/00450/56130/57670.pdf https://archimer.ifremer.fr/doc/00450/56130/57671.pdf LA English DT Article AB Marine diseases have major impacts on ecosystems and economic consequences for aquaculture and fisheries. Understanding origin, spread and risk factors of disease is crucial for management, but data in the ocean are limited compared to the terrestrial environment. Here we investigated how the marine environment drives the spread of viral disease outbreak affecting The Pacific oyster worldwide by using a spatial epidemiology framework. We collected environmental and oyster health data at 46 sites spread over an area of 300 km2 along an inshore-offshore gradient during an epizootic event and conducted risk analysis. We found that disease broke out in the intertidal farming area and spread seaward. Mortalities and virus detection were observed in oysters placed 2 km from the farming areas, but oysters of almost all sites were subclinically infected. Increasing food quantity and quality, growth rate and energy reserves of oyster were associated with a lower risk of mortality offshore whereas increasing turbidity, a proxy of the concentration of suspended particulate matter, and terrestrial inputs, inferred from fatty acid composition of oysters, were associated with a higher risk of mortality. Offshore farming and maintenance of good ecological status of coastal waters are options to limit disease risk in oysters. PY 2018 PD JUN SO Scientific Reports SN 2045-2322 PU Nature Publishing Group VL 8 IS 1 UT 000439026000030 DI 10.1038/s41598-018-29238-4 ID 56130 ER EF